Reactome | Activated NTRK2 signals through CDK5

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Activated NTRK2 signals through CDK5 Show undefined attributes

authored	[InstanceEdit:9034391] Orlic-Milacic, Marija, 2018-01-05
created	[InstanceEdit:9032844] Orlic-Milacic, Marija, 2017-12-18
dbId	9032845
displayName	Activated NTRK2 signals through CDK5
edited	[InstanceEdit:9037703] Orlic-Milacic, Marija, 2018-02-20
eventOf	[Pathway:R-HSA-9006115] Signaling by NTRK2 (TRKB) - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-9032841] Activated NTRK2 binds CDK5 - Homo sapiens [Reaction:R-HSA-9032854] NTRK2 phosphorylates CDK5 - Homo sapiens [Reaction:R-HSA-9032863] CDK5 phosphorylates NTRK2 - Homo sapiens [Reaction:R-HSA-9033276] NTRK2 binds TIAM1 - Homo sapiens [BlackBoxEvent:R-HSA-9033284] NTRK2 promotes TIAM1 phosphorylation - Homo sapiens [Reaction:R-HSA-9033292] NTRK2 and CDK5 promote activation of RAC1 by TIAM1 - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9032846] Cdk5 is involved in BDNF-stimulated dendritic growth in hippocampal neurons [LiteratureReference:9033267] TrkB phosphorylation by Cdk5 is required for activity-dependent structural plasticity and spatial memory [LiteratureReference:9032984] Mechanism underlying activity-dependent insertion of TrkB into the neuronal surface [LiteratureReference:9033352] The BDNF/TrkB signaling pathway is involved in heat hyperalgesia mediated by Cdk5 in rats
maxDepth	2
modified	[InstanceEdit:9939476] Orlic-Milacic, Marija, 2025-02-27
name	Activated NTRK2 signals through CDK5
releaseDate	2018-03-21
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9037707] Antila, Hanna, 2018-02-13 [InstanceEdit:9037710] Castr�n, Eero, 2018-02-13
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-9032845
summation	[Summation:9033301] CDK5, in complex with its activator CDK5R1 (p35), binds to B...

Referrals

(hasEvent)

[Pathway:R-HSA-9006115] Signaling by NTRK2 (TRKB)