Reactome | Activated NTRK2 signals through FRS2 and FRS3

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Activated NTRK2 signals through FRS2 and FRS3 Show undefined attributes

authored	[InstanceEdit:9034391] Orlic-Milacic, Marija, 2018-01-05
created	[InstanceEdit:9028732] Orlic-Milacic, Marija, 2017-11-09
dbId	9028731
displayName	Activated NTRK2 signals through FRS2 and FRS3
edited	[InstanceEdit:9037703] Orlic-Milacic, Marija, 2018-02-20
eventOf	[Pathway:R-HSA-9006115] Signaling by NTRK2 (TRKB) - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:182] neurotrophin TRK receptor signaling pathway
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-9028730] Activated NTRK2 binds FRS2 - Homo sapiens [Reaction:R-HSA-9028728] NTRK2 phosphorylates FRS2 - Homo sapiens [BlackBoxEvent:R-HSA-9032073] NTRK2-phosphorylated FRS2 binds GRB2 - Homo sapiens [Reaction:R-HSA-9031981] NTRK2-phosphorylated FRS2 binds PTPN11 - Homo sapiens [BlackBoxEvent:R-HSA-9032067] NTRK2 activates RAS signaling through FRS2 - Homo sapiens [Reaction:R-HSA-9032402] Activated NTRK2 binds FRS3 - Homo sapiens [Reaction:R-HSA-9032426] NTRK2 phosphorylates FRS3 - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9031570] Brain-derived neurotrophic factor induces phosphorylation of fibroblast growth factor receptor substrate 2 [LiteratureReference:9026808] Early BDNF, NT-3, and NT-4 signaling events [LiteratureReference:9031564] Structural insights into FRS2? PTB domain recognition by neurotrophin receptor TrkB [LiteratureReference:9031568] Trk receptor binding and neurotrophin/fibroblast growth factor (FGF)-dependent activation of the FGF receptor substrate (FRS)-3 [LiteratureReference:9031991] The protein tyrosine phosphatase, Shp2, is required for the complete activation of the RAS/MAPK pathway by brain-derived neurotrophic factor
modified	[InstanceEdit:10560457] Wright, Adam, 2024-03-07
name	Activated NTRK2 signals through FRS2 and FRS3
orthologousEvent	[Pathway:R-GGA-9028731] Activated NTRK2 signals through FRS2 and FRS3 - Gallus gallus [Pathway:R-XTR-9028731] Activated NTRK2 signals through FRS2 and FRS3 - Xenopus tropicalis [Pathway:R-SSC-9028731] Activated NTRK2 signals through FRS2 and FRS3 - Sus scrofa [Pathway:R-BTA-9028731] Activated NTRK2 signals through FRS2 and FRS3 - Bos taurus [Pathway:R-CFA-9028731] Activated NTRK2 signals through FRS2 and FRS3 - Canis familiaris [Pathway:R-RNO-9028731] Activated NTRK2 signals through FRS2 and FRS3 - Rattus norvegicus [Pathway:R-MMU-9028731] Activated NTRK2 signals through FRS2 and FRS3 - Mus musculus
releaseDate	2018-03-21
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9037707] Antila, Hanna, 2018-02-13 [InstanceEdit:9037710] Castr�n, Eero, 2018-02-13
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-9028731
summation	[Summation:9033471] Adapter proteins FRS2 and FRS3 can both bind to the cytoplas...

Referrals

(hasEvent)

[Pathway:R-HSA-9006115] Signaling by NTRK2 (TRKB)

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