Reactome | NTF4 activates NTRK2 (TRKB) signaling

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NTF4 activates NTRK2 (TRKB) signaling Show undefined attributes

authored	[InstanceEdit:9034391] Orlic-Milacic, Marija, 2018-01-05
created	[InstanceEdit:9026359] Orlic-Milacic, Marija, 2017-10-19
dbId	9026357
displayName	NTF4 activates NTRK2 (TRKB) signaling
edited	[InstanceEdit:9037703] Orlic-Milacic, Marija, 2018-02-20
eventOf	[Pathway:R-HSA-9006115] Signaling by NTRK2 (TRKB) - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:172228] positive regulation of neurotrophin TRK receptor signaling pathway
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-9026358] NTF4 binds NTRK2 - Homo sapiens [Reaction:R-HSA-9026377] NTF4-bound NTRK2 dimerizes - Homo sapiens [Reaction:R-HSA-9026510] NTF4-bound NTRK2 dimers trans-autophosphorylate - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9026441] Cultured hippocampal neurons show responses to BDNF, NT-3, and NT-4, but not NGF [LiteratureReference:9026442] The trkB tyrosine protein kinase is a receptor for neurotrophin-4 [LiteratureReference:9026486] Point mutation in trkB causes loss of NT4-dependent neurons without major effects on diverse BDNF responses [LiteratureReference:9025040] TrkB dimerization during development of the prefrontal cortex of the macaque
maxDepth	2
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	NTF4 activates NTRK2 (TRKB) signaling
releaseDate	2018-03-21
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9037707] Antila, Hanna, 2018-02-13 [InstanceEdit:9037710] Castr�n, Eero, 2018-02-13
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-9026357
summation	[Summation:9033450] Signaling by the neurotrophin receptor tyrosine kinase NTRK2...

Referrals

(hasEvent)

[Pathway:R-HSA-9006115] Signaling by NTRK2 (TRKB)

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