Reactome | BDNF activates NTRK2 (TRKB) signaling

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BDNF activates NTRK2 (TRKB) signaling Show undefined attributes

authored	[InstanceEdit:9034391] Orlic-Milacic, Marija, 2018-01-05
created	[InstanceEdit:9024912] Orlic-Milacic, Marija, 2017-10-10
dbId	9024909
displayName	BDNF activates NTRK2 (TRKB) signaling
edited	[InstanceEdit:9037703] Orlic-Milacic, Marija, 2018-02-20
eventOf	[Pathway:R-HSA-9006115] Signaling by NTRK2 (TRKB) - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:172228] positive regulation of neurotrophin TRK receptor signaling pathway
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-9024906] BDNF binds NTRK2 (TRKB) - Homo sapiens [Reaction:R-HSA-9024967] BDNF-bound NTRK2 dimerizes - Homo sapiens [Reaction:R-HSA-9026464] BDNF-bound NTRK2 dimers trans-autophosphorylate - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9026585] Identification of in vivo brain-derived neurotrophic factor-stimulated autophosphorylation sites on the TrkB receptor tyrosine kinase by site-directed mutagenesis [LiteratureReference:9024955] The trkB tyrosine protein kinase is a receptor for brain-derived neurotrophic factor and neurotrophin-3 [LiteratureReference:9026468] The TrkB receptor tyrosine kinase regulates cellular proliferation via signal transduction pathways involving SHC, PLCgamma, and CBL [LiteratureReference:9026486] Point mutation in trkB causes loss of NT4-dependent neurons without major effects on diverse BDNF responses [LiteratureReference:9025040] TrkB dimerization during development of the prefrontal cortex of the macaque [LiteratureReference:9024942] The neurotrophic factors brain-derived neurotrophic factor and neurotrophin-3 are ligands for the trkB tyrosine kinase receptor
maxDepth	2
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	BDNF activates NTRK2 (TRKB) signaling
releaseDate	2018-03-21
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9037707] Antila, Hanna, 2018-02-13 [InstanceEdit:9037710] Castr�n, Eero, 2018-02-13
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-9024909
summation	[Summation:9033442] Signaling by the neurotrophin receptor tyrosine kinase NTRK2...

Referrals

(hasEvent)

[Pathway:R-HSA-9006115] Signaling by NTRK2 (TRKB)