Reactome | Activated NTRK2 signals through FYN

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Activated NTRK2 signals through FYN Show undefined attributes

authored	[InstanceEdit:9034391] Orlic-Milacic, Marija, 2018-01-05
created	[InstanceEdit:9032505] Orlic-Milacic, Marija, 2017-12-13
dbId	9032500
displayName	Activated NTRK2 signals through FYN
edited	[InstanceEdit:9037703] Orlic-Milacic, Marija, 2018-02-20
eventOf	[Pathway:R-HSA-9006115] Signaling by NTRK2 (TRKB) - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:182] neurotrophin TRK receptor signaling pathway
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-9032502] Activated NTRK2 binds FYN - Homo sapiens [BlackBoxEvent:R-HSA-9032532] NTRK2-bound FYN autophosphorylates - Homo sapiens [BlackBoxEvent:R-HSA-9032582] Activated FYN binds GRIN2B - Homo sapiens [BlackBoxEvent:R-HSA-9032601] FYN-mediated phosphorylation of GRIN2B - Homo sapiens [Pathway:R-HSA-9032759] NTRK2 activates RAC1 - Homo sapiens [Reaction:R-HSA-9037040] SRC,FYN phosphorylate NTRK2 - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9032521] Association of the Src family tyrosine kinase Fyn with TrkB [LiteratureReference:9032550] Involvement of BDNF receptor TrkB in spatial memory formation [LiteratureReference:9032624] Growth factor-mediated Fyn signaling regulates alpha-amino-3- hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor expression in rodent neocortical neurons [LiteratureReference:9032656] Regulation of Na(v)1.2 channels by brain-derived neurotrophic factor, TrkB, and associated Fyn kinase [LiteratureReference:9032672] Fyn is an intermediate kinase that BDNF utilizes to promote oligodendrocyte myelination [LiteratureReference:9032668] A role for Fyn in Trk receptor transactivation by G-protein-coupled receptor signaling [LiteratureReference:9032673] Mutual regulation of Src family kinases and the neurotrophin receptor TrkB
maxDepth	3
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	Activated NTRK2 signals through FYN
orthologousEvent	[Pathway:R-GGA-9032500] Activated NTRK2 signals through FYN - Gallus gallus [Pathway:R-SSC-9032500] Activated NTRK2 signals through FYN - Sus scrofa [Pathway:R-CFA-9032500] Activated NTRK2 signals through FYN - Canis familiaris [Pathway:R-RNO-9032500] Activated NTRK2 signals through FYN - Rattus norvegicus [Pathway:R-MMU-9032500] Activated NTRK2 signals through FYN - Mus musculus
releaseDate	2018-03-21
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9037707] Antila, Hanna, 2018-02-13 [InstanceEdit:9037710] Castr�n, Eero, 2018-02-13
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-9032500
summation	[Summation:9032627] In mouse brain, Fyn activation downstream of Bdnf-induced Nt...

Referrals

(hasEvent)

[Pathway:R-HSA-9006115] Signaling by NTRK2 (TRKB)

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