Reactome | Activated NTRK2 signals through RAS

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Activated NTRK2 signals through RAS Show undefined attributes

authored	[InstanceEdit:9034391] Orlic-Milacic, Marija, 2018-01-05
created	[InstanceEdit:9026522] Orlic-Milacic, Marija, 2017-10-19
crossReference	[DatabaseIdentifier:12819507] BioModels Database:BIOMD0000000466 [DatabaseIdentifier:12819449] BioModels Database:BIOMD0000000940 [DatabaseIdentifier:12819511] BioModels Database:BIOMD0000000468 [DatabaseIdentifier:12819485] BioModels Database:BIOMD0000000424
dbId	9026519
displayName	Activated NTRK2 signals through RAS
edited	[InstanceEdit:9037703] Orlic-Milacic, Marija, 2018-02-20
eventOf	[Pathway:R-HSA-9006115] Signaling by NTRK2 (TRKB) - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:25395] positive regulation of Ras protein signal transduction
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-9026493] p-Y516 of p-5Y-NTRK2 recruits SHC1 - Homo sapiens [Reaction:R-HSA-9026890] NTRK2 phosphorylates SHC1 - Homo sapiens [Reaction:R-HSA-9028328] SHC1 bound to activated NTRK2 recruits GRB2:SOS1 - Homo sapiens [Reaction:R-HSA-9026891] NTRK2 activates RAS signaling through SHC1 - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9026468] The TrkB receptor tyrosine kinase regulates cellular proliferation via signal transduction pathways involving SHC, PLCgamma, and CBL [LiteratureReference:9026486] Point mutation in trkB causes loss of NT4-dependent neurons without major effects on diverse BDNF responses [LiteratureReference:9026808] Early BDNF, NT-3, and NT-4 signaling events
maxDepth	2
modified	[InstanceEdit:12819426] Weiser, Joel, 2026-02-23
name	Activated NTRK2 signals through RAS
releaseDate	2018-03-21
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9037707] Antila, Hanna, 2018-02-13 [InstanceEdit:9037710] Castr�n, Eero, 2018-02-13
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-9026519
summation	[Summation:9033453] Activation of the neurotrophin receptor NTRK2 (TRKB) by BDNF...

Referrals

(hasEvent)

[Pathway:R-HSA-9006115] Signaling by NTRK2 (TRKB)