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Entries
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
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authored
[InstanceEdit:8938982] Orlic-Milacic, Marija, 2016-09-14
created
[InstanceEdit:8936460] Orlic-Milacic, Marija, 2016-08-19
dbId
8936459
displayName
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
edited
[InstanceEdit:9005626] Orlic-Milacic, Marija, 2017-05-09
eventOf
[Pathway:R-HSA-8878171] Transcriptional regulation by RUNX1 - Homo sapiens
goBiologicalProcess
[GO_BiologicalProcess:24122] regulation of megakaryocyte differentiation
hasDiagram
true
hasEHLD
false
hasEvent
[Reaction:R-HSA-8934742] RUNX1 binds PRMT1 - Homo sapiens
[Reaction:R-HSA-8934735] PRMT1 arginine-methylates RUNX1 - Homo sapiens
[Reaction:R-HSA-8935740] RUNX1 and GATA1 bind the promoter of the ITGA2B gene - Homo sapiens
[Reaction:R-HSA-8936481] Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter - Homo sapiens
[Reaction:R-HSA-8935732] RUNX1 binds SIN3A,(SIN3B) co-repressor - Homo sapiens
[Reaction:R-HSA-8935730] RUNX1:CBFB, SIN3A(SIN3B), PRMT6 and HDAC1 bind the ITGA2B promoter - Homo sapiens
[Reaction:R-HSA-8936584] PRMT6 arginine methylates H3K4me2-Nucleosome at the ITGA2B gene promoter - Homo sapiens
[BlackBoxEvent:R-HSA-8935731] ITGA2B gene transcription is stimulated by the complex of RUNX1, GATA1 and PRMT1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 - Homo sapiens
[Reaction:R-HSA-8936599] RUNX1:CBFB, SIN3A(SIN3B), PRMT6 and HDAC1 bind the GP1BA promoter - Homo sapiens
[Reaction:R-HSA-8936608] PRMT6 arginine methylates H3K4me2-Nucleosome at the GP1BA gene promoter - Homo sapiens
[Reaction:R-HSA-8936616] RUNX1 and GATA1 bind the promoter of the GP1BA gene - Homo sapiens
[Reaction:R-HSA-8936621] Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter - Homo sapiens
[BlackBoxEvent:R-HSA-8936628] GP1BA gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 - Homo sapiens
[Reaction:R-HSA-8936979] RUNX1 and GATA1 bind the promoter of the THBS1 gene - Homo sapiens
[Reaction:R-HSA-8937016] Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter - Homo sapiens
[Reaction:R-HSA-8936989] RUNX1:CBFB, SIN3A(SIN3B), PRMT6 and HDAC1 bind the THBS1 gene promoter - Homo sapiens
[Reaction:R-HSA-8937022] PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter - Homo sapiens
[BlackBoxEvent:R-HSA-8936995] THBS1 gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 - Homo sapiens
[Reaction:R-HSA-8937037] RUNX1 and GATA1 bind the promoter of the MIR27A gene - Homo sapiens
[Reaction:R-HSA-8937050] Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter - Homo sapiens
[Reaction:R-HSA-8937118] RUNX1:CBFB, SIN3A(SIN3B), PRMT6 and HDAC1 bind the MIR27A gene promoter - Homo sapiens
[Reaction:R-HSA-8937113] PRMT6 arginine methylates H3K4me2-Nucleosome at the MIR27A gene promoter - Homo sapiens
[BlackBoxEvent:R-HSA-8937097] MIR27A gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 - Homo sapiens
[Reaction:R-HSA-8938176] RUNX1:CBFB binds the PF4 gene promoter - Homo sapiens
[BlackBoxEvent:R-HSA-8938174] PF4 gene transcription is stimulated by RUNX1:CBFB - Homo sapiens
[Reaction:R-HSA-8938022] RUNX1:CBFB binds the NR4A3 gene promoter - Homo sapiens
[BlackBoxEvent:R-HSA-8938034] NR4A3 gene expression is stimulated by RUNX1:CBFB - Homo sapiens
[Reaction:R-HSA-8938150] RUNX1:CBFB binds the PRKCQ gene promoter - Homo sapiens
[BlackBoxEvent:R-HSA-8938158] PRKCQ gene expression is stimulated by RUNX1:CBFB - Homo sapiens
[Reaction:R-HSA-8938199] RUNX1:CBFB binds the MYL9 gene promoter - Homo sapiens
[BlackBoxEvent:R-HSA-8938201] MYL9 gene transcription is stimulated by RUNX1:CBFB - Homo sapiens
[Reaction:R-HSA-8938328] RUNX1:CBFB binds the NFE2 gene promoter - Homo sapiens
[BlackBoxEvent:R-HSA-8938338] NFE2 gene expression is stimulated by RUNX1:CBFB - Homo sapiens
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:8936545] RUNX1 and GATA-1 coexpression and cooperation in megakaryocytic differentiation
[LiteratureReference:8936554] Physical association of the patient-specific GATA1 mutants with RUNX1 in acute megakaryoblastic leukemia accompanying Down syndrome
[LiteratureReference:8936397] Histone arginine methylation keeps RUNX1 target genes in an intermediate state
[LiteratureReference:8934723] Methylation of RUNX1 by PRMT1 abrogates SIN3A binding and potentiates its transcriptional activity
[LiteratureReference:8936716] Platelet glycoprotein IIb gene expression as a model of megakaryocyte-specific expression
[LiteratureReference:8936692] Structural determinants within platelet glycoprotein Ibalpha involved in its binding to von Willebrand factor
[LiteratureReference:8936702] Glycoprotein Ib polymorphisms influence platelet plug formation under high shear rates
[LiteratureReference:8936712] Expression of platelet glycoprotein Ib by cultured human megakaryocytes: ultrastructural localization and biosynthesis
[LiteratureReference:8936996] Thrombospondin-1 in von Willebrand factor function
[LiteratureReference:8937040] A regulatory interplay between miR-27a and Runx1 during megakaryopoiesis
[LiteratureReference:8938179] Mechanism of platelet factor 4 (PF4) deficiency with RUNX1 haplodeficiency: RUNX1 is a transcriptional regulator of PF4
[LiteratureReference:8938017] Down-regulation of the RUNX1-target gene NR4A3 contributes to hematopoiesis deregulation in familial platelet disorder/acute myelogenous leukemia
[LiteratureReference:8938151] Platelet protein kinase C-theta deficiency with human RUNX1 mutation: PRKCQ is a transcriptional target of RUNX1
[LiteratureReference:8938200] Regulation of platelet myosin light chain (MYL9) by RUNX1: implications for thrombocytopenia and platelet dysfunction in RUNX1 haplodeficiency
[LiteratureReference:8938333] AML1 is overexpressed in patients with myeloproliferative neoplasms and mediates JAK2V617F-independent overexpression of NF-E2
modified
[InstanceEdit:10740525] Wright, Adam, 2024-03-08
name
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
orthologousEvent
[Pathway:R-MMU-8936459] RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function - Mus musculus
[Pathway:R-RNO-8936459] RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function - Rattus norvegicus
[Pathway:R-CFA-8936459] RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function - Canis familiaris
[Pathway:R-BTA-8936459] RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function - Bos taurus
[Pathway:R-SSC-8936459] RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function - Sus scrofa
[Pathway:R-DME-8936459] RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function - Drosophila melanogaster
[Pathway:R-CEL-8936459] RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function - Caenorhabditis elegans
[Pathway:R-DRE-8936459] RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function - Danio rerio
[Pathway:R-XTR-8936459] RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function - Xenopus tropicalis
[Pathway:R-GGA-8936459] RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function - Gallus gallus
releaseDate
2017-06-12
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9005627] Ito, Yoshiaki, 2016-12-20
[InstanceEdit:9005628] Chuang, Linda Shyue Huey, 2016-12-20
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-8936459
summation
[Summation:8936543] In human hematopoietic progenitors, RUNX1 and its partner CB...
Referrals
(hasEvent)
[Pathway:R-HSA-8878171] Transcriptional regulation by RUNX1
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