Reactome | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function

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RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Show undefined attributes

created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10225087
displayName	RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
eventOf	[Pathway:R-RNO-8878171] Transcriptional regulation by RUNX1 - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:24122] regulation of megakaryocyte differentiation
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-RNO-8934742] RUNX1 binds PRMT1 - Rattus norvegicus [Reaction:R-RNO-8934735] PRMT1 arginine-methylates RUNX1 - Rattus norvegicus [Reaction:R-RNO-8936481] Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter - Rattus norvegicus [Reaction:R-RNO-8935732] RUNX1 binds SIN3A,(SIN3B) co-repressor - Rattus norvegicus [Reaction:R-RNO-8936584] PRMT6 arginine methylates H3K4me2-Nucleosome at the ITGA2B gene promoter - Rattus norvegicus [Reaction:R-RNO-8936608] PRMT6 arginine methylates H3K4me2-Nucleosome at the GP1BA gene promoter - Rattus norvegicus [Reaction:R-RNO-8936621] Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter - Rattus norvegicus [Reaction:R-RNO-8937016] Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter - Rattus norvegicus [Reaction:R-RNO-8937022] PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter - Rattus norvegicus [Reaction:R-RNO-8937050] Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter - Rattus norvegicus [Reaction:R-RNO-8937113] PRMT6 arginine methylates H3K4me2-Nucleosome at the MIR27A gene promoter - Rattus norvegicus
inferredFrom	[Pathway:R-HSA-8936459] RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48895] Rattus norvegicus
stId	R-RNO-8936459
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-8878171] Transcriptional regulation by RUNX1
(inferredTo)	[Pathway:R-HSA-8936459] RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function

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