Reactome | RUNX1 and GATA1 bind the promoter of the GP1BA gene

Schema > Reaction > Entries

RUNX1 and GATA1 bind the promoter of the GP1BA gene Show undefined attributes

authored	[InstanceEdit:8938982] Orlic-Milacic, Marija, 2016-09-14
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:8936613] Orlic-Milacic, Marija, 2016-08-22
dbId	8936616
displayName	RUNX1 and GATA1 bind the promoter of the GP1BA gene
edited	[InstanceEdit:9005626] Orlic-Milacic, Marija, 2017-05-09
eventOf	[Pathway:R-HSA-8936459] RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function - Homo sapiens
input	[CandidateSet:R-HSA-5244738] Core MLL complex [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-381325] EP300 [nucleoplasm] [Complex:R-HSA-8936469] GATA1:ZFPM1 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-8936595] GP1BA gene [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-352430] KAT2B [nucleoplasm] [Complex:R-HSA-1214200] Nucleosome with H3K4me2 [nucleoplasm] [DefinedSet:R-HSA-8935716] RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8934723] Methylation of RUNX1 by PRMT1 abrogates SIN3A binding and potentiates its transcriptional activity [LiteratureReference:8936397] Histone arginine methylation keeps RUNX1 target genes in an intermediate state [LiteratureReference:8936545] RUNX1 and GATA-1 coexpression and cooperation in megakaryocytic differentiation [LiteratureReference:8936554] Physical association of the patient-specific GATA1 mutants with RUNX1 in acute megakaryoblastic leukemia accompanying Down syndrome [LiteratureReference:8936467] Molecular cloning and characterization of the GATA1 cofactor human FOG1 and assessment of its binding to GATA1 proteins carrying D218 substitutions
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	RUNX1 and GATA1 bind the promoter of the GP1BA gene
output	[Complex:R-HSA-8936615] H3K4me2-Nucleosome:GP1BA gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm]
precedingEvent	[Reaction:R-HSA-8865320] CBFB binds RUNX1 - Homo sapiens [Reaction:R-HSA-8934735] PRMT1 arginine-methylates RUNX1 - Homo sapiens
releaseDate	2017-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9005627] Ito, Yoshiaki, 2016-12-20 [InstanceEdit:9005628] Chuang, Linda Shyue Huey, 2016-12-20
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8936616
summation	[Summation:8936614] The RUNX1:CBFB complex can bind to the promoter of the GP1BA...

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[Pathway:R-HSA-8936459] RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function