Reactome | PF4 gene transcription is stimulated by RUNX1:CBFB

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PF4 gene transcription is stimulated by RUNX1:CBFB Show undefined attributes

authored	[InstanceEdit:8938982] Orlic-Milacic, Marija, 2016-09-14
category	omitted
compartment	[Compartment:7660] nucleoplasm [Compartment:114506] platelet alpha granule lumen
created	[InstanceEdit:8938180] Orlic-Milacic, Marija, 2016-09-08
dbId	8938174
displayName	PF4 gene transcription is stimulated by RUNX1:CBFB
edited	[InstanceEdit:9005626] Orlic-Milacic, Marija, 2017-05-09
eventOf	[Pathway:R-HSA-8936459] RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-8938181] PF4 gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8938179] Mechanism of platelet factor 4 (PF4) deficiency with RUNX1 haplodeficiency: RUNX1 is a transcriptional regulator of PF4
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	PF4 gene transcription is stimulated by RUNX1:CBFB
output	[DefinedSet:R-HSA-8938182] PF4 [platelet alpha granule lumen]
precedingEvent	[Reaction:R-HSA-8938176] RUNX1:CBFB binds the PF4 gene promoter - Homo sapiens
regulatedBy	[PositiveGeneExpressionRegulation:R-HSA-8938184] Positive gene expression regulation by 'RUNX1:CBFB:PF4 gene [nucleoplasm]'
regulationReference	[RegulationReference:9642934] Positive gene expression regulation by 'RUNX1:CBFB:PF4 gene [nucleoplasm]' Mechanism of platelet factor 4 (PF4) deficiency with RUNX1 haplodeficiency: RUNX1 is a transcriptional regulator of PF4
releaseDate	2017-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9005627] Ito, Yoshiaki, 2016-12-20 [InstanceEdit:9005628] Chuang, Linda Shyue Huey, 2016-12-20
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-8938174
summation	[Summation:8938177] Binding of the RUNX1:CBFB complex to the promoter of the PF4...

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(hasEvent)

[Pathway:R-HSA-8936459] RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function

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