Reactome | Histone arginine methylation keeps RUNX1 target genes in an intermediate state

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Histone arginine methylation keeps RUNX1 target genes in an intermediate state Show undefined attributes

author	[Person:8936396] Herglotz, J [Person:8936401] Kuvardina, ON [Person:8936398] Kolodziej, S [Person:5320920] Kumar, A [Person:8936395] Hussong, H [Person:8936400] Grez, M [Person:8936402] Lausen, J
created	[InstanceEdit:8936399] Orlic-Milacic, Marija, 2016-08-18
dbId	8936397
displayName	Histone arginine methylation keeps RUNX1 target genes in an intermediate state
journal	Oncogene
pages	2565-75
pubMedIdentifier	22777353
schemaClass	LiteratureReference
title	Histone arginine methylation keeps RUNX1 target genes in an intermediate state
url	http://www.ncbi.nlm.nih.gov/pubmed/22777353
volume	32
year	2013

Referrals

(author)

[Person:8936395] Hussong, H
[Person:8936396] Herglotz, J
[Person:8936398] Kolodziej, S
[Person:8936400] Grez, M
[Person:8936401] Kuvardina, ON
[Person:5320920] Kumar, A
[Person:8936402] Lausen, J

(literatureReference)

[Pathway:R-HSA-8936459] RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
[Summation:8936696] The RUNX1:CBFB complex binds the promoter of the GP1BA (CD42...
[BlackBoxEvent:R-HSA-8936628] GP1BA gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6
[RegulationReference:9641599] Positive gene expression regulation by 'H3K4me3-Nucleosome:GP1BA gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm]' Histone arginine methylation keeps RUNX1 target genes in an intermediate state
[RegulationReference:9642730] Negative gene expression regulation by 'RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:GP1BA gene:H3K4me2,H3R2me2a-Nucleosome [nucleoplasm]' Histone arginine methylation keeps RUNX1 target genes in an intermediate state
[Summation:8935739] The RUNX1:CBFB complex binds the promoter of the ITGA2B (CD4...
[BlackBoxEvent:R-HSA-8935731] ITGA2B gene transcription is stimulated by the complex of RUNX1, GATA1 and PRMT1 and inhibited by the complex of RUNX1, SIN3A and PRMT6
[RegulationReference:9641545] Positive gene expression regulation by 'H3K4me3-Nucleosome:ITGA2B gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm]' Methylation of RUNX1 by PRMT1 abrogates SIN3A binding and potentiates its transcriptional activity
[RegulationReference:9642363] Negative gene expression regulation by 'RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:ITGA2B gene:H3K4me2,H3R2me2a-Nucleosome [nucleoplasm]' Methylation of RUNX1 by PRMT1 abrogates SIN3A binding and potentiates its transcriptional activity
[Reaction:R-HSA-8937016] Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter
[CatalystActivityReference:9643559] histone methyltransferase activity (H3-K4 specific) of H3K4me2-Nucleosome:THBS1 gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] Histone arginine methylation keeps RUNX1 target genes in an intermediate state
[Summation:8936994] The RUNX1:CBFB complex binds the promoter of the THBS1 (TSP-...
[Complex:R-HSA-8935726] RUNX1:CBFB:SIN3A(SIN3B):PRMT6:HDAC1 [nucleoplasm]
[Complex:R-HSA-8935719] RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:ITGA2B gene:H3K4me2-Nucleosome [nucleoplasm]
[CatalystActivityReference:9643720] histone-arginine N-methyltransferase activity of RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:ITGA2B gene:H3K4me2-Nucleosome [nucleoplasm] Histone arginine methylation keeps RUNX1 target genes in an intermediate state
[Complex:R-HSA-8936586] RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:ITGA2B gene:H3K4me2,H3R2me2a-Nucleosome [nucleoplasm]
[Reaction:R-HSA-8935732] RUNX1 binds SIN3A,(SIN3B) co-repressor
[Reaction:R-HSA-8935730] RUNX1:CBFB, SIN3A(SIN3B), PRMT6 and HDAC1 bind the ITGA2B promoter
[Reaction:R-HSA-8936584] PRMT6 arginine methylates H3K4me2-Nucleosome at the ITGA2B gene promoter
[Complex:R-HSA-8936477] RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm]
[Complex:R-HSA-8937048] H3K4me3-Nucleosome:MIR27A gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm]
[Complex:R-HSA-8937112] RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:MIR27A gene:H3K4me2,H3R2me2a-Nucleosome [nucleoplasm]
[RegulationReference:9641719] Negative gene expression regulation by 'RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:MIR27A gene:H3K4me2,H3R2me2a-Nucleosome [nucleoplasm]' Histone arginine methylation keeps RUNX1 target genes in an intermediate state
[RegulationReference:9641534] Positive gene expression regulation by 'H3K4me3-Nucleosome:MIR27A gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm]' Histone arginine methylation keeps RUNX1 target genes in an intermediate state
[BlackBoxEvent:R-HSA-8937097] MIR27A gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6
[Complex:R-HSA-8937036] H3K4me2-Nucleosome:MIR27A gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm]
[Reaction:R-HSA-8937037] RUNX1 and GATA1 bind the promoter of the MIR27A gene
[Complex:R-HSA-8937114] RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:MIR27A gene:H3K4me2-Nucleosome [nucleoplasm]
[Reaction:R-HSA-8937118] RUNX1:CBFB, SIN3A(SIN3B), PRMT6 and HDAC1 bind the MIR27A gene promoter
[Reaction:R-HSA-8937113] PRMT6 arginine methylates H3K4me2-Nucleosome at the MIR27A gene promoter
[CatalystActivityReference:9644019] histone methyltransferase activity (H3-K4 specific) of H3K4me2-Nucleosome:MIR27A gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] Histone arginine methylation keeps RUNX1 target genes in an intermediate state
[Reaction:R-HSA-8937050] Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter
[Complex:R-HSA-8936988] RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:THBS1 gene:H3K4me2-Nucleosome [nucleoplasm]
[Reaction:R-HSA-8936989] RUNX1:CBFB, SIN3A(SIN3B), PRMT6 and HDAC1 bind the THBS1 gene promoter
[Complex:R-HSA-8936977] H3K4me2-Nucleosome:THBS1 gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm]
[Reaction:R-HSA-8936979] RUNX1 and GATA1 bind the promoter of the THBS1 gene
[Complex:R-HSA-8936600] RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:GP1BA gene:H3K4me2-Nucleosome [nucleoplasm]
[Reaction:R-HSA-8936599] RUNX1:CBFB, SIN3A(SIN3B), PRMT6 and HDAC1 bind the GP1BA promoter
[Complex:R-HSA-8936615] H3K4me2-Nucleosome:GP1BA gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm]
[Reaction:R-HSA-8936616] RUNX1 and GATA1 bind the promoter of the GP1BA gene
[CatalystActivityReference:9643384] histone methyltransferase activity (H3-K4 specific) of H3K4me2-Nucleosome:GP1BA gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] Histone arginine methylation keeps RUNX1 target genes in an intermediate state
[Complex:R-HSA-8936620] H3K4me3-Nucleosome:GP1BA gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm]
[Reaction:R-HSA-8936621] Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter
[CatalystActivityReference:9643306] histone-arginine N-methyltransferase activity of RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:GP1BA gene:H3K4me2-Nucleosome [nucleoplasm] Histone arginine methylation keeps RUNX1 target genes in an intermediate state
[Complex:R-HSA-8936607] RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:GP1BA gene:H3K4me2,H3R2me2a-Nucleosome [nucleoplasm]
[Reaction:R-HSA-8936608] PRMT6 arginine methylates H3K4me2-Nucleosome at the GP1BA gene promoter
[CatalystActivityReference:9643364] histone methyltransferase activity (H3-K4 specific) of H3K4me2-Nucleosome:ITGA2B gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] Histone arginine methylation keeps RUNX1 target genes in an intermediate state
[Reaction:R-HSA-8935740] RUNX1 and GATA1 bind the promoter of the ITGA2B gene
[Reaction:R-HSA-8936481] Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter
[Complex:R-HSA-8937013] H3K4me3-Nucleosome:THBS1 gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm]
[Complex:R-HSA-8937024] RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:THBS1B gene:H3K4me2,H3R2me2a-Nucleosome [nucleoplasm]
[RegulationReference:9641808] Negative gene expression regulation by 'RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:THBS1B gene:H3K4me2,H3R2me2a-Nucleosome [nucleoplasm]' Histone arginine methylation keeps RUNX1 target genes in an intermediate state
[RegulationReference:9642701] Positive gene expression regulation by 'H3K4me3-Nucleosome:THBS1 gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm]' Histone arginine methylation keeps RUNX1 target genes in an intermediate state
[BlackBoxEvent:R-HSA-8936995] THBS1 gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6

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