Reactome | RUNX1:CBFB, SIN3A(SIN3B), PRMT6 and HDAC1 bind the THBS1 gene promoter

Schema > Reaction > Entries

RUNX1:CBFB, SIN3A(SIN3B), PRMT6 and HDAC1 bind the THBS1 gene promoter Show undefined attributes

authored	[InstanceEdit:8938982] Orlic-Milacic, Marija, 2016-09-14
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:8936987] Orlic-Milacic, Marija, 2016-08-25
dbId	8936989
displayName	RUNX1:CBFB, SIN3A(SIN3B), PRMT6 and HDAC1 bind the THBS1 gene promoter
edited	[InstanceEdit:9005626] Orlic-Milacic, Marija, 2017-05-09
eventOf	[Pathway:R-HSA-8936459] RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function - Homo sapiens
followingEvent	[Reaction:R-HSA-8937022] PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter - Homo sapiens
input	[Complex:R-HSA-1214200] Nucleosome with H3K4me2 [nucleoplasm] [Complex:R-HSA-8935726] RUNX1:CBFB:SIN3A(SIN3B):PRMT6:HDAC1 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-8936978] THBS1 gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8934723] Methylation of RUNX1 by PRMT1 abrogates SIN3A binding and potentiates its transcriptional activity [LiteratureReference:8936397] Histone arginine methylation keeps RUNX1 target genes in an intermediate state [LiteratureReference:8937012] Thrombospondin-1 is a transcriptional repression target of PRMT6
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	RUNX1:CBFB, SIN3A(SIN3B), PRMT6 and HDAC1 bind the THBS1 gene promoter
output	[Complex:R-HSA-8936988] RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:THBS1 gene:H3K4me2-Nucleosome [nucleoplasm]
releaseDate	2017-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9005627] Ito, Yoshiaki, 2016-12-20 [InstanceEdit:9005628] Chuang, Linda Shyue Huey, 2016-12-20
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8936989
summation	[Summation:8936986] The transcriptional co-repressor SIN3A (and possibly SIN3B) ...

Referrals

(precedingEvent)	[Reaction:R-HSA-8937022] PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter
(hasEvent)	[Pathway:R-HSA-8936459] RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function

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