Reactome | RUNX2 binds CBFB

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RUNX2 binds CBFB Show undefined attributes

authored	[InstanceEdit:8865412] Orlic-Milacic, Marija, 2016-03-22
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:8865412] Orlic-Milacic, Marija, 2016-03-22
dbId	8865425
displayName	RUNX2 binds CBFB
edited	[InstanceEdit:9015316] Orlic-Milacic, Marija, 2017-08-09
eventOf	[Pathway:R-HSA-8878166] Transcriptional regulation by RUNX2 - Homo sapiens
followingEvent	[Reaction:R-HSA-8938371] RUNX2:CBFB binds the LGALS3 gene promoter - Homo sapiens [Reaction:R-HSA-8939670] RUNX2:CBFB binds the ITGA5 gene promoter - Homo sapiens [Reaction:R-HSA-8939963] Activated AKT phosphorylates RUNX2 - Homo sapiens [Reaction:R-HSA-8939833] RUNX2:CBFB binds the ITGBL1 gene promoter - Homo sapiens [Reaction:R-HSA-9009451] RUNX2 binds SMURF1 gene - Homo sapiens [Reaction:R-HSA-9009282] CDK1 phosphorylates RUNX2 - Homo sapiens [Reaction:R-HSA-8878257] RUNX2 binds the IHH gene promoter - Homo sapiens [Reaction:R-HSA-8939852] RUNX2 and SP7 bind the UCMA gene promoter - Homo sapiens [Reaction:R-HSA-9008877] RUNX2:CBFB binds BGLAP gene promoter - Homo sapiens [Reaction:R-HSA-9009208] Activated ERKs phosphorylate RUNX2 - Homo sapiens [Reaction:R-HSA-8877941] RUNX2 binds SMAD1 in the nucleus - Homo sapiens [Reaction:R-HSA-9008412] CDK4 phosphorylates RUNX2 - Homo sapiens [Reaction:R-HSA-8937864] RUNX2 binds tyrosine phosphorylated YAP1 - Homo sapiens [Reaction:R-HSA-9008433] RUNX2 binds CDKN1A gene promoter - Homo sapiens
inferredFrom	[Reaction:R-MMU-8865408] Cbfb binds Runx2 - Mus musculus
input	[EntityWithAccessionedSequence:R-HSA-8865293] CBFB [nucleoplasm] [CandidateSet:R-HSA-9007751] RUNX2 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:8865398] Cbfbeta interacts with Runx2 and has a critical role in bone development [LiteratureReference:8865422] Core-binding factor beta interacts with Runx2 and is required for skeletal development [LiteratureReference:8865426] Cbf? deletion in mice recapitulates cleidocranial dysplasia and reveals multiple functions of Cbf? required for skeletal development [LiteratureReference:8865395] Mutations in the RUNX2 gene in patients with cleidocranial dysplasia [LiteratureReference:9015211] Missense mutations abolishing DNA binding of the osteoblast-specific transcription factor OSF2/CBFA1 in cleidocranial dysplasia [LiteratureReference:9015201] Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	RUNX2 binds CBFB
output	[Complex:R-HSA-8865420] RUNX2:CBFB [nucleoplasm]
precedingEvent	[BlackBoxEvent:R-HSA-9007999] RUNX2 translocates to the nucleus - Homo sapiens
releaseDate	2017-09-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9015314] Ducy, Patricia, 2017-08-04
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8865425
summation	[Summation:8865416] RUNX2 (CBFA1 or AML3) forms a complex with CBFB. RUNX2 gene ...

Referrals

(precedingEvent)	[Reaction:R-HSA-8938371] RUNX2:CBFB binds the LGALS3 gene promoter [Reaction:R-HSA-8939670] RUNX2:CBFB binds the ITGA5 gene promoter [Reaction:R-HSA-8939963] Activated AKT phosphorylates RUNX2 [Reaction:R-HSA-8939833] RUNX2:CBFB binds the ITGBL1 gene promoter [Reaction:R-HSA-9009451] RUNX2 binds SMURF1 gene [Reaction:R-HSA-9009282] CDK1 phosphorylates RUNX2 [Reaction:R-HSA-8878257] RUNX2 binds the IHH gene promoter [Reaction:R-HSA-8939852] RUNX2 and SP7 bind the UCMA gene promoter [Reaction:R-HSA-9008877] RUNX2:CBFB binds BGLAP gene promoter [Reaction:R-HSA-9009208] Activated ERKs phosphorylate RUNX2 [Reaction:R-HSA-8937864] RUNX2 binds tyrosine phosphorylated YAP1 [Reaction:R-HSA-8877941] RUNX2 binds SMAD1 in the nucleus [Reaction:R-HSA-9008433] RUNX2 binds CDKN1A gene promoter [Reaction:R-HSA-9008412] CDK4 phosphorylates RUNX2
(hasEvent)	[Pathway:R-HSA-8878166] Transcriptional regulation by RUNX2
(inferredTo)	[Reaction:R-MMU-8865408] Cbfb binds Runx2

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