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Reaction
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Entries
RUNX2 binds SMAD1 in the nucleus
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authored
[InstanceEdit:8877934] Orlic-Milacic, Marija, 2016-06-28
category
binding
compartment
[Compartment:7660] nucleoplasm
created
[InstanceEdit:8877934] Orlic-Milacic, Marija, 2016-06-28
dbId
8877941
displayName
RUNX2 binds SMAD1 in the nucleus
edited
[InstanceEdit:9015316] Orlic-Milacic, Marija, 2017-08-09
eventOf
[Pathway:R-HSA-8941326] RUNX2 regulates bone development - Homo sapiens
followingEvent
[Reaction:R-HSA-8878013] RUNX2 and SMAD1 complex binds the SMAD6 gene promoter - Homo sapiens
input
[Complex:R-HSA-206654] p-2S-SMAD1:p-2S-SMAD1:SMAD4 [nucleoplasm]
[Complex:R-HSA-8865420] RUNX2:CBFB [nucleoplasm]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:8877937] Bone morphogenetic protein 2 activates Smad6 gene transcription through bone-specific transcription factor Runx2
maxDepth
1
modified
[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name
RUNX2 binds SMAD1 in the nucleus
orthologousEvent
[Reaction:R-CFA-8877941] RUNX2 binds SMAD1 in the nucleus - Canis familiaris
[Reaction:R-CEL-8877941] RUNX2 binds SMAD1 in the nucleus - Caenorhabditis elegans
[Reaction:R-DME-8877941] RUNX2 binds SMAD1 in the nucleus - Drosophila melanogaster
[Reaction:R-GGA-8877941] RUNX2 binds SMAD1 in the nucleus - Gallus gallus
[Reaction:R-XTR-8877941] RUNX2 binds SMAD1 in the nucleus - Xenopus tropicalis
[Reaction:R-SSC-8877941] RUNX2 binds SMAD1 in the nucleus - Sus scrofa
[Reaction:R-BTA-8877941] RUNX2 binds SMAD1 in the nucleus - Bos taurus
[Reaction:R-MMU-8877941] RUNX2 binds SMAD1 in the nucleus - Mus musculus
output
[Complex:R-HSA-8877936] RUNX2:CBFB:p-2S-SMAD1:p-2S-SMAD1:SMAD4 [nucleoplasm]
precedingEvent
[Reaction:R-HSA-8865425] RUNX2 binds CBFB - Homo sapiens
[Reaction:R-HSA-201472] The phospho-R-Smad1/5/8:Co-Smad transfers to the nucleus - Homo sapiens
releaseDate
2017-09-12
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9015314] Ducy, Patricia, 2017-08-04
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-8877941
summation
[Summation:8877945] In response to BMP2 treatment, RUNX2 (presumably associated ...
Referrals
(hasEvent)
[Pathway:R-HSA-8941326] RUNX2 regulates bone development
(precedingEvent)
[Reaction:R-HSA-8878013] RUNX2 and SMAD1 complex binds the SMAD6 gene promoter
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