Reactome | RUNX2 binds the IHH gene promoter

Schema > Reaction > Entries

authored	[InstanceEdit:8878253] Orlic-Milacic, Marija, 2016-06-30
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:8878253] Orlic-Milacic, Marija, 2016-06-30
dbId	8878257
displayName	RUNX2 binds the IHH gene promoter
edited	[InstanceEdit:9015316] Orlic-Milacic, Marija, 2017-08-09
eventOf	[Pathway:R-HSA-8941284] RUNX2 regulates chondrocyte maturation - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-8878266] IHH gene transcription is stimulated by RUNX2 - Homo sapiens
inferredFrom	[Reaction:R-MMU-8940989] Runx2 binds the Ihh gene promoter - Mus musculus
input	[EntityWithAccessionedSequence:R-HSA-8878254] IHH gene [nucleoplasm] [Complex:R-HSA-8865420] RUNX2:CBFB [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:8878262] Runx2 and Runx3 are essential for chondrocyte maturation, and Runx2 regulates limb growth through induction of Indian hedgehog
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	RUNX2 binds the IHH gene promoter
output	[Complex:R-HSA-8878255] RUNX2:CBFB:IHH gene [nucleoplasm]
precedingEvent	[Reaction:R-HSA-8865425] RUNX2 binds CBFB - Homo sapiens
releaseDate	2017-09-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9015314] Ducy, Patricia, 2017-08-04
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8878257
summation	[Summation:8878263] Based on studies in mice, RUNX2, presumably associated with ...

(precedingEvent)	[BlackBoxEvent:R-HSA-8878266] IHH gene transcription is stimulated by RUNX2
(hasEvent)	[Pathway:R-HSA-8941284] RUNX2 regulates chondrocyte maturation
(inferredTo)	[Reaction:R-MMU-8940989] Runx2 binds the Ihh gene promoter

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