Reactome | PRPS1 dimer pyrophosphorylates R5P using dATP

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PRPS1 dimer pyrophosphorylates R5P using dATP Show undefined attributes

catalystActivity	[CatalystActivity:73486] ribose phosphate diphosphokinase activity of PRPS1 dimer [cytosol]
catalystActivityReference	[CatalystActivityReference:9643862] ribose phosphate diphosphokinase activity of PRPS1 dimer [cytosol] Human phosphoribosylpyrophosphate synthetase
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:111216] D'Eustachio, P, 2004-02-10 11:22:00
dbId	111215
displayName	PRPS1 dimer pyrophosphorylates R5P using dATP
eventOf	[Pathway:R-HSA-73843] 5-Phosphoribose 1-diphosphate biosynthesis - Homo sapiens
followingEvent	[Reaction:R-HSA-73815] 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate - Homo sapiens [Reaction:R-HSA-73567] UMPS dimer transfers phosphoribosyl group to ORO to form OMP - Homo sapiens
input	[SimpleEntity:R-ALL-110644] dATP [cytosol] [SimpleEntity:R-ALL-73578] R5P [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:111183] Human phosphoribosylpyrophosphate synthetase [LiteratureReference:9934062] Phosphoribosyl Diphosphate (PRPP): Biosynthesis, Enzymology, Utilization, and Metabolic Significance
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	PRPS1 dimer pyrophosphorylates R5P using dATP D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate
orthologousEvent	[Reaction:R-PFA-111215] PRPS1 dimer pyrophosphorylates R5P using dATP - Plasmodium falciparum [Reaction:R-SCE-111215] PRPS1 dimer pyrophosphorylates R5P using dATP - Saccharomyces cerevisiae [Reaction:R-SPO-111215] PRPS1 dimer pyrophosphorylates R5P using dATP - Schizosaccharomyces pombe [Reaction:R-DDI-111215] PRPS1 dimer pyrophosphorylates R5P using dATP - Dictyostelium discoideum [Reaction:R-CEL-111215] PRPS1 dimer pyrophosphorylates R5P using dATP - Caenorhabditis elegans [Reaction:R-GGA-111215] PRPS1 dimer pyrophosphorylates R5P using dATP - Gallus gallus [Reaction:R-XTR-111215] PRPS1 dimer pyrophosphorylates R5P using dATP - Xenopus tropicalis [Reaction:R-DRE-111215] PRPS1 dimer pyrophosphorylates R5P using dATP - Danio rerio [Reaction:R-SSC-111215] PRPS1 dimer pyrophosphorylates R5P using dATP - Sus scrofa [Reaction:R-BTA-111215] PRPS1 dimer pyrophosphorylates R5P using dATP - Bos taurus [Reaction:R-CFA-111215] PRPS1 dimer pyrophosphorylates R5P using dATP - Canis familiaris [Reaction:R-RNO-111215] PRPS1 dimer pyrophosphorylates R5P using dATP - Rattus norvegicus [Reaction:R-MMU-111215] PRPS1 dimer pyrophosphorylates R5P using dATP - Mus musculus
output	[SimpleEntity:R-ALL-109386] dAMP [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-73566] PRPP [cytosol]
previousReviewStatus	[ReviewStatus:9821384] two stars
regulatedBy	[Requirement:R-HSA-9034457] Requirement by 'Mg2+ [cytosol]' [Requirement:R-HSA-9034462] Requirement by 'Pi [cytosol]'
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9939470] Matthews, Lisa, 2025-02-27
revised	[InstanceEdit:469644] D'Eustachio, P, 2010-01-24
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-111215
summation	[Summation:178636] Cytosolic phosphoribosyl pyrophosphate synthetase 1 catalyze...
updateTrackers	[UpdateTracker:9779731] Update Tracker - [Reaction:111215] D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate - v64:[addRegulator] [UpdateTracker:9939674] Update Tracker - [Reaction:111215] PRPS1 dimer pyrophosphorylates R5P using dATP - v92:[modifyText, removeLiteratureReference, removeOutput] [UpdateTracker:9792466] Update Tracker - [Reaction:111215] D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate - v20:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9779731] Update Tracker - [Reaction:111215] D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate - v64:[addRegulator] [UpdateTracker:9939674] Update Tracker - [Reaction:111215] PRPS1 dimer pyrophosphorylates R5P using dATP - v92:[modifyText, removeLiteratureReference, removeOutput] [UpdateTracker:9792466] Update Tracker - [Reaction:111215] D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate - v20:[modifyText]
(precedingEvent)	[Reaction:R-HSA-73567] UMPS dimer transfers phosphoribosyl group to ORO to form OMP [Reaction:R-HSA-73815] 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate
(hasEvent)	[Pathway:R-HSA-73843] 5-Phosphoribose 1-diphosphate biosynthesis

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