Reactome | PRPS dimers pyrophosphorylate R5P using ATP

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PRPS dimers pyrophosphorylate R5P using ATP Show undefined attributes

catalystActivity	[CatalystActivity:111174] ribose phosphate diphosphokinase activity of PRPS dimers [cytosol]
catalystActivityReference	[CatalystActivityReference:9643885] ribose phosphate diphosphokinase activity of PRPS2 dimer, PRPS1L dimer [cytosol] Human phosphoribosylpyrophosphate synthetase
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:73446] Jassal, B, 2003-06-17 09:00:25
crossReference	[DatabaseIdentifier:12667754] RHEA:15610 [DatabaseIdentifier:9934050] RHEA:15610
dbId	73580
deleted	[Deleted:189811] Deletion of instance: 111211 [Deleted:189815] Deletion of instance: 111214
displayName	PRPS dimers pyrophosphorylate R5P using ATP
eventOf	[Pathway:R-HSA-73843] 5-Phosphoribose 1-diphosphate biosynthesis - Homo sapiens
followingEvent	[Reaction:R-HSA-73815] 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate - Homo sapiens [Reaction:R-HSA-73567] UMPS dimer transfers phosphoribosyl group to ORO to form OMP - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-73578] R5P [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:111183] Human phosphoribosylpyrophosphate synthetase [LiteratureReference:9934062] Phosphoribosyl Diphosphate (PRPP): Biosynthesis, Enzymology, Utilization, and Metabolic Significance
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	PRPS dimers pyrophosphorylate R5P using ATP D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate addition of diphosphate (PP) to ribose 5-phosphate to form 5'-Phospho-alpha-D-ribose 1-diphosphate (PRPP)
orthologousEvent	[Reaction:R-PFA-73580] PRPS dimers pyrophosphorylate R5P using ATP - Plasmodium falciparum [Reaction:R-SCE-73580] PRPS dimers pyrophosphorylate R5P using ATP - Saccharomyces cerevisiae [Reaction:R-SPO-73580] PRPS dimers pyrophosphorylate R5P using ATP - Schizosaccharomyces pombe [Reaction:R-DDI-73580] PRPS dimers pyrophosphorylate R5P using ATP - Dictyostelium discoideum [Reaction:R-CEL-73580] PRPS dimers pyrophosphorylate R5P using ATP - Caenorhabditis elegans [Reaction:R-GGA-73580] PRPS dimers pyrophosphorylate R5P using ATP - Gallus gallus [Reaction:R-XTR-73580] PRPS dimers pyrophosphorylate R5P using ATP - Xenopus tropicalis [Reaction:R-DRE-73580] PRPS dimers pyrophosphorylate R5P using ATP - Danio rerio [Reaction:R-SSC-73580] PRPS dimers pyrophosphorylate R5P using ATP - Sus scrofa [Reaction:R-BTA-73580] PRPS dimers pyrophosphorylate R5P using ATP - Bos taurus [Reaction:R-CFA-73580] PRPS dimers pyrophosphorylate R5P using ATP - Canis familiaris [Reaction:R-RNO-73580] PRPS dimers pyrophosphorylate R5P using ATP - Rattus norvegicus [Reaction:R-MMU-73580] PRPS dimers pyrophosphorylate R5P using ATP - Mus musculus
output	[SimpleEntity:R-ALL-76577] AMP [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-73566] PRPP [cytosol]
precedingEvent	[Reaction:R-HSA-71306] RPIA isomerizes D-ribulose 5-phosphate to ribose 5-phosphate - Homo sapiens
previousReviewStatus	[ReviewStatus:9821384] two stars
regulatedBy	[Requirement:R-HSA-9034457] Requirement by 'Mg2+ [cytosol]' [Requirement:R-HSA-9034462] Requirement by 'Pi [cytosol]'
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9939470] Matthews, Lisa, 2025-02-27
revised	[InstanceEdit:469644] D'Eustachio, P, 2010-01-24
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-73580
summation	[Summation:178637] Cytosolic phophoribosyl pyrophosphate synthetase catalyzes t...
updateTrackers	[UpdateTracker:9939744] Update Tracker - [Reaction:73580] PRPS dimers pyrophosphorylate R5P using ATP - v92:[modifyText, removeLiteratureReference, removeOutput, removeRegulator] [UpdateTracker:9792530] Update Tracker - [Reaction:73580] D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate - v20:[add_removeCatalystActivity, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9939744] Update Tracker - [Reaction:73580] PRPS dimers pyrophosphorylate R5P using ATP - v92:[modifyText, removeLiteratureReference, removeOutput, removeRegulator] [UpdateTracker:9792530] Update Tracker - [Reaction:73580] D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate - v20:[add_removeCatalystActivity, modifyText]
(replacementInstances)	[Deleted:189811] Deletion of instance: 111211 [Deleted:189815] Deletion of instance: 111214
(precedingEvent)	[Reaction:R-HSA-73567] UMPS dimer transfers phosphoribosyl group to ORO to form OMP [Reaction:R-HSA-73815] 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate
(hasEvent)	[Pathway:R-HSA-73843] 5-Phosphoribose 1-diphosphate biosynthesis