Reactome | Pyrimidine biosynthesis

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Pyrimidine biosynthesis Show undefined attributes

authored	[InstanceEdit:504063] D'Eustachio, P, 2010-02-05
compartment	[Compartment:70101] cytosol [Compartment:70616] mitochondrial inner membrane [Compartment:7660] nucleoplasm
created	[InstanceEdit:500750] D'Eustachio, P, 2010-02-04
dbId	500753
deleted	[Deleted:504061] Deletion of instance: 73648 [Deleted:8959453] Deletion of instance: 73848
displayName	Pyrimidine biosynthesis
edited	[InstanceEdit:517475] D'Eustachio, P, 2010-02-18
eventOf	[Pathway:R-HSA-8956320] Nucleotide biosynthesis - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:22926] pyrimidine nucleoside biosynthetic process
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-73577] CAD hexamer transforms L-Gln to CAP - Homo sapiens [Reaction:R-HSA-73573] CAD hexamer transforms CAP to N-carb-L-Asp - Homo sapiens [Reaction:R-HSA-73571] CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO - Homo sapiens [Reaction:R-HSA-73569] DHODH:FMN oxidises (S)-DHO to orotate - Homo sapiens [Reaction:R-HSA-9708759] DHODH:FMN binds DHODH inhibitors - Homo sapiens [Reaction:R-HSA-73567] UMPS dimer transfers phosphoribosyl group to ORO to form OMP - Homo sapiens [Reaction:R-HSA-73564] UMPS dimer decarboxylates OMP to UMP - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2022-06-09
literatureReference	[LiteratureReference:76627] Pyrimidine nucleotide biosynthesis in animals: genes, enzymes, and regulation of UMP biosynthesis
maxDepth	2
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	Pyrimidine biosynthesis
orthologousEvent	[Pathway:R-MMU-500753] Pyrimidine biosynthesis - Mus musculus [Pathway:R-PFA-500753] Pyrimidine biosynthesis - Plasmodium falciparum [Pathway:R-SCE-500753] Pyrimidine biosynthesis - Saccharomyces cerevisiae [Pathway:R-SPO-500753] Pyrimidine biosynthesis - Schizosaccharomyces pombe [Pathway:R-DDI-500753] Pyrimidine biosynthesis - Dictyostelium discoideum [Pathway:R-CEL-500753] Pyrimidine biosynthesis - Caenorhabditis elegans [Pathway:R-DME-500753] Pyrimidine biosynthesis - Drosophila melanogaster [Pathway:R-GGA-500753] Pyrimidine biosynthesis - Gallus gallus [Pathway:R-XTR-500753] Pyrimidine biosynthesis - Xenopus tropicalis [Pathway:R-DRE-500753] Pyrimidine biosynthesis - Danio rerio [Pathway:R-SSC-500753] Pyrimidine biosynthesis - Sus scrofa [Pathway:R-BTA-500753] Pyrimidine biosynthesis - Bos taurus [Pathway:R-CFA-500753] Pyrimidine biosynthesis - Canis familiaris [Pathway:R-RNO-500753] Pyrimidine biosynthesis - Rattus norvegicus
releaseDate	2010-03-16
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:165071] Graves, L, Rush, MG, 0000-00-00 00:00:00
revised	[InstanceEdit:504064] D'Eustachio, P, 2010-02-05
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-500753
summation	[Summation:73582] The pyrimidine orotate (orotic acid) is synthesized in a seq...
updateTrackers	[UpdateTracker:9776009] Update Tracker - [Pathway:500753] Pyrimidine biosynthesis - v78:[updateContainedRLE] [UpdateTracker:9774753] Update Tracker - [Pathway:500753] Pyrimidine biosynthesis - v81:[addHasEvent] [UpdateTracker:9781586] Update Tracker - [Pathway:500753] Pyrimidine biosynthesis - v60:[removeHasEvent, removeLiteratureReference]

Referrals

(updatedInstance)	[UpdateTracker:9776009] Update Tracker - [Pathway:500753] Pyrimidine biosynthesis - v78:[updateContainedRLE] [UpdateTracker:9774753] Update Tracker - [Pathway:500753] Pyrimidine biosynthesis - v81:[addHasEvent] [UpdateTracker:9781586] Update Tracker - [Pathway:500753] Pyrimidine biosynthesis - v60:[removeHasEvent, removeLiteratureReference]
(replacementInstances)	[Deleted:504061] Deletion of instance: 73648 [Deleted:8959453] Deletion of instance: 73848
(hasEvent)	[Pathway:R-HSA-8956320] Nucleotide biosynthesis

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