Reactome | UMPS dimer decarboxylates OMP to UMP

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UMPS dimer decarboxylates OMP to UMP Show undefined attributes

authored	[InstanceEdit:73446] Jassal, B, 2003-06-17 09:00:25
catalystActivity	[CatalystActivity:73492] orotidine-5'-phosphate decarboxylase activity of UMPS dimer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:73446] Jassal, B, 2003-06-17 09:00:25
crossReference	[DatabaseIdentifier:12668047] RHEA:11597 [DatabaseIdentifier:9975776] RHEA:11597
dbId	73564
displayName	UMPS dimer decarboxylates OMP to UMP
edited	[InstanceEdit:165080] D'Eustachio, P, 0000-00-00 00:00:00
eventOf	[Pathway:R-HSA-500753] Pyrimidine biosynthesis - Homo sapiens
followingEvent	[Reaction:R-HSA-73548] (d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) - Homo sapiens
input	[SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-111629] OMP [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:111648] Molecular cloning of the human UMP synthase gene and characterization of point mutations in two hereditary orotic aciduria families [LiteratureReference:419511] Intrinsic activity and stability of bifunctional human UMP synthase and its two separate catalytic domains, orotate phosphoribosyltransferase and orotidine-5'-phosphate decarboxylase [LiteratureReference:419510] Structures of the human orotidine-5'-monophosphate decarboxylase support a covalent mechanism and provide a framework for drug design [LiteratureReference:111659] Isolation and initial characterization of the single polypeptide that synthesizes uridine 5'-monophosphate from orotate in Ehrlich ascites carcinoma. Purification by tandem affinity chromatography of uridine-5'-monophosphate synthase
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	UMPS dimer decarboxylates OMP to UMP orotidine 5'-phosphate + H(+) => UMP + CO2 orotidine 5'-monophosphate => uridine 5'-monophosphate + CO2 decarboxylation of Orotidine 5'-phosphate to form Uridine 5'-phosphate
orthologousEvent	[Reaction:R-GGA-419461] orotidine 5'-monophosphate => uridine 5'-monophosphate + CO2 - Gallus gallus [Reaction:R-MMU-73564] UMPS dimer decarboxylates OMP to UMP - Mus musculus [Reaction:R-DDI-73564] UMPS dimer decarboxylates OMP to UMP - Dictyostelium discoideum [Reaction:R-CEL-73564] UMPS dimer decarboxylates OMP to UMP - Caenorhabditis elegans [Reaction:R-DME-73564] UMPS dimer decarboxylates OMP to UMP - Drosophila melanogaster [Reaction:R-GGA-73564] UMPS dimer decarboxylates OMP to UMP - Gallus gallus [Reaction:R-XTR-73564] UMPS dimer decarboxylates OMP to UMP - Xenopus tropicalis [Reaction:R-DRE-73564] UMPS dimer decarboxylates OMP to UMP - Danio rerio [Reaction:R-SSC-73564] UMPS dimer decarboxylates OMP to UMP - Sus scrofa [Reaction:R-BTA-73564] UMPS dimer decarboxylates OMP to UMP - Bos taurus [Reaction:R-CFA-73564] UMPS dimer decarboxylates OMP to UMP - Canis familiaris [Reaction:R-RNO-73564] UMPS dimer decarboxylates OMP to UMP - Rattus norvegicus
output	[SimpleEntity:R-ALL-113528] CO2 [cytosol] [SimpleEntity:R-ALL-109402] UMP [cytosol]
precedingEvent	[Reaction:R-HSA-73567] UMPS dimer transfers phosphoribosyl group to ORO to form OMP - Homo sapiens
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:504064] D'Eustachio, P, 2010-02-05
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-73564
summation	[Summation:111663] The decarboxylation of orotidine 5'-monophosphate (OMP) to f...
updateTrackers	[UpdateTracker:9776004] Update Tracker - [Reaction:73564] UMPS dimer decarboxylates OMP to UMP - v78:[addInput] [UpdateTracker:9791493] Update Tracker - [Reaction:73564] UMPS dimer decarboxylates OMP to UMP - v29:[addLiteratureReference, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9776004] Update Tracker - [Reaction:73564] UMPS dimer decarboxylates OMP to UMP - v78:[addInput] [UpdateTracker:9791493] Update Tracker - [Reaction:73564] UMPS dimer decarboxylates OMP to UMP - v29:[addLiteratureReference, modifyText]
(precedingEvent)	[Reaction:R-HSA-73548] (d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1)
(hasEvent)	[Pathway:R-HSA-500753] Pyrimidine biosynthesis