Reactome | DHODH:FMN oxidises (S)-DHO to orotate

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DHODH:FMN oxidises (S)-DHO to orotate Show undefined attributes

authored	[InstanceEdit:73446] Jassal, B, 2003-06-17 09:00:25
catalystActivity	[CatalystActivity:73535] dihydroorotate dehydrogenase activity of DHODH:FMN [mitochondrial inner membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:70616] mitochondrial inner membrane
created	[InstanceEdit:73446] Jassal, B, 2003-06-17 09:00:25
crossReference	[DatabaseIdentifier:9975770] RHEA:28692
dbId	73569
displayName	DHODH:FMN oxidises (S)-DHO to orotate
edited	[InstanceEdit:165080] D'Eustachio, P, 0000-00-00 00:00:00
eventOf	[Pathway:R-HSA-500753] Pyrimidine biosynthesis - Homo sapiens
followingEvent	[Reaction:R-HSA-73567] UMPS dimer transfers phosphoribosyl group to ORO to form OMP - Homo sapiens
input	[SimpleEntity:R-ALL-76630] (S)-DHO [cytosol] [SimpleEntity:R-ALL-73663] CoQ [mitochondrial inner membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:76627] Pyrimidine nucleotide biosynthesis in animals: genes, enzymes, and regulation of UMP biosynthesis [LiteratureReference:76613] Superoxide production and electron transport in mitochondrial oxidation of dihydroorotic acid [LiteratureReference:76616] Expression, purification, and characterization of histidine-tagged rat and human flavoenzyme dihydroorotate dehydrogenase [LiteratureReference:76621] Indirect inhibition of mitochondrial dihydroorotate dehydrogenase activity by nitric oxide [LiteratureReference:111664] Enzymic synthesis and breakdown of a pyrimidine, orotic acid. I. Dihydro-orotic dehydrogenase
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	DHODH:FMN oxidises (S)-DHO to orotate S)-dihydroorotate + a ubiquinone => orotate + a ubiquinol (S)-dihydroorotate + ubiquinone => orotate + ubiquinol oxidation of (S)-Dihydroorotate to form Orotate
orthologousEvent	[Reaction:R-GGA-419452] (S)-dihydroorotate + ubiquinone => orotate + ubiquinol - Gallus gallus [Reaction:R-MMU-73569] DHODH:FMN oxidises (S)-DHO to orotate - Mus musculus [Reaction:R-PFA-73569] DHODH:FMN oxidises (S)-DHO to orotate - Plasmodium falciparum [Reaction:R-SPO-73569] DHODH:FMN oxidises (S)-DHO to orotate - Schizosaccharomyces pombe [Reaction:R-CEL-73569] DHODH:FMN oxidises (S)-DHO to orotate - Caenorhabditis elegans [Reaction:R-DME-73569] DHODH:FMN oxidises (S)-DHO to orotate - Drosophila melanogaster [Reaction:R-GGA-73569] DHODH:FMN oxidises (S)-DHO to orotate - Gallus gallus [Reaction:R-XTR-73569] DHODH:FMN oxidises (S)-DHO to orotate - Xenopus tropicalis [Reaction:R-DRE-73569] DHODH:FMN oxidises (S)-DHO to orotate - Danio rerio [Reaction:R-SSC-73569] DHODH:FMN oxidises (S)-DHO to orotate - Sus scrofa [Reaction:R-BTA-73569] DHODH:FMN oxidises (S)-DHO to orotate - Bos taurus [Reaction:R-CFA-73569] DHODH:FMN oxidises (S)-DHO to orotate - Canis familiaris [Reaction:R-RNO-73569] DHODH:FMN oxidises (S)-DHO to orotate - Rattus norvegicus
output	[SimpleEntity:R-ALL-76632] ORO [cytosol] [SimpleEntity:R-ALL-76633] QH2 [mitochondrial inner membrane]
precedingEvent	[Reaction:R-HSA-73571] CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO - Homo sapiens
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:504064] D'Eustachio, P, 2010-02-05
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-73569
summation	[Summation:76631] Dihydroorotate dehydrogenase catalyzes the oxidation of dihy...
updateTrackers	[UpdateTracker:9791495] Update Tracker - [Reaction:73569] DHODH:FMN oxidises (S)-DHO to orotate - v29:[addLiteratureReference, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9791495] Update Tracker - [Reaction:73569] DHODH:FMN oxidises (S)-DHO to orotate - v29:[addLiteratureReference, modifyText]
(hasEvent)	[Pathway:R-HSA-500753] Pyrimidine biosynthesis
(precedingEvent)	[Reaction:R-HSA-73567] UMPS dimer transfers phosphoribosyl group to ORO to form OMP