Reactome | UMPS dimer transfers phosphoribosyl group to ORO to form OMP

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UMPS dimer transfers phosphoribosyl group to ORO to form OMP Show undefined attributes

catalystActivity	[CatalystActivity:10735207] orotate phosphoribosyltransferase activity of UMPS dimer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10735209
displayName	UMPS dimer transfers phosphoribosyl group to ORO to form OMP
eventOf	[Pathway:R-GGA-500753] Pyrimidine biosynthesis - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-GGA-73564] UMPS dimer decarboxylates OMP to UMP - Gallus gallus [Reaction:R-GGA-71732] PPA1 hydrolyzes pyrophosphate to orthophosphate - Gallus gallus
inferredFrom	[Reaction:R-HSA-73567] UMPS dimer transfers phosphoribosyl group to ORO to form OMP - Homo sapiens
input	[SimpleEntity:R-ALL-76632] ORO [cytosol] [SimpleEntity:R-ALL-73566] PRPP [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	UMPS dimer transfers phosphoribosyl group to ORO to form OMP orotate + 5-phospho-alpha-D-ribose 1-diphosphate => orotidine 5'-phosphate + diphosphate orotate + 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) <=> orotidine 5'-monophosphate (OMP) + pyrophosphate phosphoribosylation of orotate to form oritidine 5'-phosphate (OMP)
output	[SimpleEntity:R-ALL-111629] OMP [cytosol] [SimpleEntity:R-ALL-111294] PPi [cytosol]
precedingEvent	[Reaction:R-GGA-73569] DHODH:FMN oxidises (S)-DHO to orotate - Gallus gallus [Reaction:R-GGA-111215] PRPS1 dimer pyrophosphorylates R5P using dATP - Gallus gallus [Reaction:R-GGA-73580] PRPS dimers pyrophosphorylate R5P using ATP - Gallus gallus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-73567
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(precedingEvent)	[Reaction:R-GGA-71732] PPA1 hydrolyzes pyrophosphate to orthophosphate [Reaction:R-GGA-73564] UMPS dimer decarboxylates OMP to UMP
(hasEvent)	[Pathway:R-GGA-500753] Pyrimidine biosynthesis
(inferredTo)	[Reaction:R-HSA-73567] UMPS dimer transfers phosphoribosyl group to ORO to form OMP

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