Reactome | Inactivation of Cyclin E:Cdk2 complexes by p27/p21

Schema > Reaction > Entries

Inactivation of Cyclin E:Cdk2 complexes by p27/p21 Show undefined attributes

catalystActivity	[CatalystActivity:188223] cyclin-dependent protein serine/threonine kinase inhibitor activity of CDKN1A,CDKN1B [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:69508] Khanna, K, 2003-06-05 08:03:38
dbId	69562
deleted	[Deleted:617367] Deletion of instance: 187994 [Deleted:737639] Deletion of instance: 69911 [Deleted:737634] Deletion of instance: 69909
displayName	Inactivation of Cyclin E:Cdk2 complexes by p27/p21
edited	[InstanceEdit:188201] Matthews, L, 2006-10-02 07:13:54 [InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
eventOf	[Pathway:R-HSA-69563] p53-Dependent G1 DNA Damage Response - Homo sapiens [Pathway:R-HSA-6804116] TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest - Homo sapiens [Pathway:R-HSA-69202] Cyclin E associated events during G1/S transition - Homo sapiens [Pathway:R-HSA-2559586] DNA Damage/Telomere Stress Induced Senescence - Homo sapiens
figure	[Figure:69455] /figures/p53_dep_inactivation.jpg
followingEvent	[Reaction:R-HSA-187520] Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21 - Homo sapiens
input	[Complex:R-HSA-68374] CCNE:CDK2 [nucleoplasm] [DefinedSet:R-HSA-182558] CDKN1A,CDKN1B [nucleoplasm]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:187515] Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation [LiteratureReference:187793] Ubiquitination of p21Cip1/WAF1 by SCFSkp2: substrate requirement and ubiquitination site selection [LiteratureReference:69417] The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases.
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	Inactivation of Cyclin E:Cdk2 complexes by p27/p21
orthologousEvent	[Reaction:R-CEL-69562] Inactivation of Cyclin E:Cdk2 complexes by p27/p21 - Caenorhabditis elegans [Reaction:R-DME-69562] Inactivation of Cyclin E:Cdk2 complexes by p27/p21 - Drosophila melanogaster [Reaction:R-GGA-69562] Inactivation of Cyclin E:Cdk2 complexes by p27/p21 - Gallus gallus [Reaction:R-XTR-69562] Inactivation of Cyclin E:Cdk2 complexes by p27/p21 - Xenopus tropicalis [Reaction:R-DRE-69562] Inactivation of Cyclin E:Cdk2 complexes by p27/p21 - Danio rerio [Reaction:R-SSC-69562] Inactivation of Cyclin E:Cdk2 complexes by p27/p21 - Sus scrofa [Reaction:R-BTA-69562] Inactivation of Cyclin E:Cdk2 complexes by p27/p21 - Bos taurus [Reaction:R-CFA-69562] Inactivation of Cyclin E:Cdk2 complexes by p27/p21 - Canis familiaris [Reaction:R-RNO-69562] Inactivation of Cyclin E:Cdk2 complexes by p27/p21 - Rattus norvegicus [Reaction:R-MMU-69562] Inactivation of Cyclin E:Cdk2 complexes by p27/p21 - Mus musculus
output	[Complex:R-HSA-68376] Cyclin E:CDK2:CDKN1A,CDKN1B [nucleoplasm]
precedingEvent	[Reaction:R-HSA-157906] Translocation of Cyclin E:Cdk2 complex to the nucleus - Homo sapiens [Reaction:R-HSA-187828] Translocation of p21 to the nucleus - Homo sapiens [Reaction:R-HSA-187506] Translocation of p27 to the nucleoplasm - Homo sapiens [Reaction:R-HSA-69199] Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A - Homo sapiens [BlackBoxEvent:R-HSA-6803411] PCBP4 modulates CDKN1A translation - Homo sapiens [BlackBoxEvent:R-HSA-4647613] Transcriptional activation of CDKN1A by TP53 is inhibited by EP400 - Homo sapiens
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8855677] Zaccara, Sara, 2016-02-04 [InstanceEdit:8855680] Inga, Alberto, 2016-02-04
revised	[InstanceEdit:188183] Matthews, L, 2006-10-02 06:19:16
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-69562
summation	[Summation:187795] During G1, the activity of cyclin-dependent kinases (CDKs) i...
updateTrackers	[UpdateTracker:9783373] Update Tracker - [Reaction:69562] Inactivation of Cyclin E:Cdk2 complexes by p27/p21 - v56:[modifyText] [UpdateTracker:9787237] Update Tracker - [Reaction:69562] Inactivation of Cyclin E:Cdk2 complexes by p27/p21 - v46:[addLiteratureReference]

Referrals

(updatedInstance)	[UpdateTracker:9783373] Update Tracker - [Reaction:69562] Inactivation of Cyclin E:Cdk2 complexes by p27/p21 - v56:[modifyText] [UpdateTracker:9787237] Update Tracker - [Reaction:69562] Inactivation of Cyclin E:Cdk2 complexes by p27/p21 - v46:[addLiteratureReference]
(replacementInstances)	[Deleted:617367] Deletion of instance: 187994 [Deleted:737639] Deletion of instance: 69911 [Deleted:737634] Deletion of instance: 69909
(hasEvent)	[Pathway:R-HSA-6804116] TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest [Pathway:R-HSA-2559586] DNA Damage/Telomere Stress Induced Senescence [Pathway:R-HSA-69563] p53-Dependent G1 DNA Damage Response [Pathway:R-HSA-69202] Cyclin E associated events during G1/S transition
(precedingEvent)	[Reaction:R-HSA-187520] Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21

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