Reactome | p53-Dependent G1 DNA Damage Response

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p53-Dependent G1 DNA Damage Response Show undefined attributes

created	[InstanceEdit:69508] Khanna, K, 2003-06-05 08:03:38
crossReference	[DatabaseIdentifier:12819521] BioModels Database:BIOMD0000000287 [DatabaseIdentifier:12819523] BioModels Database:BIOMD0000000157 [DatabaseIdentifier:12819525] BioModels Database:BIOMD0000000154 [DatabaseIdentifier:12819527] BioModels Database:BIOMD0000000158 [DatabaseIdentifier:12819591] BioModels Database:BIOMD0000000188 [DatabaseIdentifier:12819489] BioModels Database:BIOMD0000000939 [DatabaseIdentifier:12819529] BioModels Database:BIOMD0000000155 [DatabaseIdentifier:12819531] BioModels Database:BIOMD0000001007 [DatabaseIdentifier:12819533] BioModels Database:BIOMD0000000156 [DatabaseIdentifier:12819535] BioModels Database:BIOMD0000001009 [DatabaseIdentifier:12819581] BioModels Database:BIOMD0000000943 [DatabaseIdentifier:12819539] BioModels Database:BIOMD0000001010 [DatabaseIdentifier:12819541] BioModels Database:BIOMD0000000159 [DatabaseIdentifier:12819593] BioModels Database:BIOMD0000000634 [DatabaseIdentifier:12819661] BioModels Database:BIOMD0000000189 [DatabaseIdentifier:12819545] BioModels Database:BIOMD0000001006
dbId	69563
displayName	p53-Dependent G1 DNA Damage Response
eventOf	[Pathway:R-HSA-69580] p53-Dependent G1/S DNA damage checkpoint - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:22659] DNA damage response, signal transduction by p53 class mediator
hasDiagram	false
hasEHLD	false
hasEvent	[Pathway:R-HSA-69541] Stabilization of p53 - Homo sapiens [Pathway:R-HSA-69560] Transcriptional activation of p53 responsive genes - Homo sapiens [Reaction:R-HSA-69562] Inactivation of Cyclin E:Cdk2 complexes by p27/p21 - Homo sapiens [Reaction:R-HSA-187934] Inactivation of Cyclin A:Cdk2 complexes by p27/p21 - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2019-06-12
literatureReference	[LiteratureReference:69564] Mdm2 promotes the rapid degradation of p53. [LiteratureReference:69567] Regulation of p53 stability by Mdm2. [LiteratureReference:69571] A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia. [LiteratureReference:69578] Ionizing radiation and UV induction of p53 protein by different pathways in ataxia-telangiectasia cells.
maxDepth	4
modified	[InstanceEdit:12819426] Weiser, Joel, 2026-02-23
name	p53-Dependent G1 DNA Damage Response
orthologousEvent	[Pathway:R-MMU-69563] p53-Dependent G1 DNA Damage Response - Mus musculus [Pathway:R-RNO-69563] p53-Dependent G1 DNA Damage Response - Rattus norvegicus [Pathway:R-CFA-69563] p53-Dependent G1 DNA Damage Response - Canis familiaris [Pathway:R-BTA-69563] p53-Dependent G1 DNA Damage Response - Bos taurus [Pathway:R-SSC-69563] p53-Dependent G1 DNA Damage Response - Sus scrofa [Pathway:R-DRE-69563] p53-Dependent G1 DNA Damage Response - Danio rerio [Pathway:R-XTR-69563] p53-Dependent G1 DNA Damage Response - Xenopus tropicalis [Pathway:R-GGA-69563] p53-Dependent G1 DNA Damage Response - Gallus gallus [Pathway:R-DME-69563] p53-Dependent G1 DNA Damage Response - Drosophila melanogaster [Pathway:R-CEL-69563] p53-Dependent G1 DNA Damage Response - Caenorhabditis elegans [Pathway:R-DDI-69563] p53-Dependent G1 DNA Damage Response - Dictyostelium discoideum
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:165074] Manfredi, James J
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-69563
summation	[Summation:69579] Most of the damage-induced modifications of p53 are dependen...
updateTrackers	[UpdateTracker:9791289] Update Tracker - [Pathway:69563] p53-Dependent G1 DNA Damage Response - v31:[updateContainedPathway] [UpdateTracker:9792014] Update Tracker - [Pathway:69563] p53-Dependent G1 DNA Damage Response - v24:[updateContainedPathway] [UpdateTracker:9783724] Update Tracker - [Pathway:69563] p53-Dependent G1 DNA Damage Response - v56:[addHasEvent, updateContainedPathway, updateContainedRLE] [UpdateTracker:9789337] Update Tracker - [Pathway:69563] p53-Dependent G1 DNA Damage Response - v38:[updateContainedPathway] [UpdateTracker:9777757] Update Tracker - [Pathway:69563] p53-Dependent G1 DNA Damage Response - v69:[updateContainedRLE] [UpdateTracker:9782857] Update Tracker - [Pathway:69563] p53-Dependent G1 DNA Damage Response - v58:[updateIndirectRLE] [UpdateTracker:9780030] Update Tracker - [Pathway:69563] p53-Dependent G1 DNA Damage Response - v64:[updateContainedRLE] [UpdateTracker:9781769] Update Tracker - [Pathway:69563] p53-Dependent G1 DNA Damage Response - v60:[updateIndirectRLE] [UpdateTracker:9784247] Update Tracker - [Pathway:69563] p53-Dependent G1 DNA Damage Response - v54:[updateContainedPathway] [UpdateTracker:9786999] Update Tracker - [Pathway:69563] p53-Dependent G1 DNA Damage Response - v46:[updateContainedPathway, updateContainedRLE]

Referrals

(hasEvent)

[Pathway:R-HSA-69580] p53-Dependent G1/S DNA damage checkpoint

(updatedInstance)

[UpdateTracker:9791289] Update Tracker - [Pathway:69563] p53-Dependent G1 DNA Damage Response - v31:[updateContainedPathway]
[UpdateTracker:9792014] Update Tracker - [Pathway:69563] p53-Dependent G1 DNA Damage Response - v24:[updateContainedPathway]
[UpdateTracker:9783724] Update Tracker - [Pathway:69563] p53-Dependent G1 DNA Damage Response - v56:[addHasEvent, updateContainedPathway, updateContainedRLE]
[UpdateTracker:9789337] Update Tracker - [Pathway:69563] p53-Dependent G1 DNA Damage Response - v38:[updateContainedPathway]
[UpdateTracker:9777757] Update Tracker - [Pathway:69563] p53-Dependent G1 DNA Damage Response - v69:[updateContainedRLE]
[UpdateTracker:9782857] Update Tracker - [Pathway:69563] p53-Dependent G1 DNA Damage Response - v58:[updateIndirectRLE]
[UpdateTracker:9780030] Update Tracker - [Pathway:69563] p53-Dependent G1 DNA Damage Response - v64:[updateContainedRLE]
[UpdateTracker:9781769] Update Tracker - [Pathway:69563] p53-Dependent G1 DNA Damage Response - v60:[updateIndirectRLE]
[UpdateTracker:9784247] Update Tracker - [Pathway:69563] p53-Dependent G1 DNA Damage Response - v54:[updateContainedPathway]
[UpdateTracker:9786999] Update Tracker - [Pathway:69563] p53-Dependent G1 DNA Damage Response - v46:[updateContainedPathway, updateContainedRLE]

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