Reactome | Transcriptional activation of CDKN1A by TP53 is inhibited by EP400

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Transcriptional activation of CDKN1A by TP53 is inhibited by EP400 Show undefined attributes

authored	[InstanceEdit:187964] Matthews, L, 2006-09-29 13:54:26
category	omitted
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:4647614] Orlic-Milacic, M, 2013-09-30
dbId	4647613
displayName	Transcriptional activation of CDKN1A by TP53 is inhibited by EP400
edited	[InstanceEdit:188346] Matthews, L, 2006-10-10 08:05:07
eventOf	[Pathway:R-HSA-2559586] DNA Damage/Telomere Stress Induced Senescence - Homo sapiens
followingEvent	[Reaction:R-HSA-187934] Inactivation of Cyclin A:Cdk2 complexes by p27/p21 - Homo sapiens [Reaction:R-HSA-69562] Inactivation of Cyclin E:Cdk2 complexes by p27/p21 - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-3786256] CDKN1A gene [nucleoplasm]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:69405] WAF1, a potential mediator of p53 tumor suppression. [LiteratureReference:4647608] The p400 E1A-associated protein is a novel component of the p53 --> p21 senescence pathway
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Transcriptional activation of CDKN1A by TP53 is inhibited by EP400
output	[EntityWithAccessionedSequence:R-HSA-182585] CDKN1A [nucleoplasm]
precedingEvent	[Reaction:R-HSA-3786258] TP53 binds the CDKN1A promoter - Homo sapiens [Reaction:R-HSA-4647593] EP400 binds CDKN1A promoter - Homo sapiens
regulatedBy	[NegativeGeneExpressionRegulation:R-HSA-4647597] Negative gene expression regulation by 'EP400:p-S15-TP53 Tetramer:CDKN1A Gene [nucleoplasm]' [PositiveGeneExpressionRegulation:R-HSA-4647606] Positive gene expression regulation by 'p-S15-TP53 Tetramer:CDKN1A Gene [nucleoplasm]'
regulationReference	[RegulationReference:9642410] Negative gene expression regulation by 'EP400:p-S15-TP53 Tetramer:CDKN1A Gene [nucleoplasm]' The p400 E1A-associated protein is a novel component of the p53 --> p21 senescence pathway
releaseDate	2013-12-04
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:4542303] Samarajiwa, Shamith, 2013-09-03
revised	[InstanceEdit:4647612] Orlic-Milacic, M, 2013-09-30
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-4647613
summation	[Summation:4647602] CDKN1A (p21) is transcriptionally activated by TP53 (p53) af...

Referrals

(hasEvent)	[Pathway:R-HSA-2559586] DNA Damage/Telomere Stress Induced Senescence
(precedingEvent)	[Reaction:R-HSA-187934] Inactivation of Cyclin A:Cdk2 complexes by p27/p21 [Reaction:R-HSA-69562] Inactivation of Cyclin E:Cdk2 complexes by p27/p21