Reactome | Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A

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Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A Show undefined attributes

authored	[InstanceEdit:72785] Joshi-Tope, G, 2003-06-12 05:55:26
catalystActivity	[CatalystActivity:69198] phosphoprotein phosphatase activity of CDC25A [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
dbId	69199
deleted	[Deleted:737637] Deletion of instance: 69693 [Deleted:737644] Deletion of instance: 69694
displayName	Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A
edited	[InstanceEdit:75992] Matthews, L, 2003-09-10 06:00:00
eventOf	[Pathway:R-HSA-69202] Cyclin E associated events during G1/S transition - Homo sapiens
figure	[Figure:72788] /figures/cycline_cdk2_dp.jpg
followingEvent	[Pathway:R-HSA-69200] Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes - Homo sapiens [Reaction:R-HSA-188350] CAK-mediated phosphorylation of Cyclin E:Cdk2 - Homo sapiens [Reaction:R-HSA-69562] Inactivation of Cyclin E:Cdk2 complexes by p27/p21 - Homo sapiens
input	[Complex:R-HSA-68377] Cyclin E:p-CDK2 [nucleoplasm] [SimpleEntity:R-ALL-113518] H2O [nucleoplasm]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:182635] Ectopic expression of Cdc25A accelerates the G(1)/S transition and leads to premature activation of cyclin E- and cyclin A-dependent kinases
maxDepth	1
modified	[InstanceEdit:11051501] Weiser, Joel, 2026-03-16
name	Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A
orthologousEvent	[Reaction:R-SPO-69199] Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A - Schizosaccharomyces pombe [Reaction:R-DDI-69199] Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A - Dictyostelium discoideum [Reaction:R-CEL-69199] Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A - Caenorhabditis elegans [Reaction:R-DME-69199] Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A - Drosophila melanogaster [Reaction:R-GGA-69199] Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A - Gallus gallus [Reaction:R-XTR-69199] Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A - Xenopus tropicalis [Reaction:R-DRE-69199] Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A - Danio rerio [Reaction:R-SSC-69199] Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A - Sus scrofa [Reaction:R-BTA-69199] Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A - Bos taurus [Reaction:R-CFA-69199] Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A - Canis familiaris [Reaction:R-RNO-69199] Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A - Rattus norvegicus [Reaction:R-MMU-69199] Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A - Mus musculus
output	[Complex:R-HSA-68374] CCNE:CDK2 [nucleoplasm] [SimpleEntity:R-ALL-113550] Pi [nucleoplasm]
precedingEvent	[Reaction:R-HSA-69195] Phosphorylation of Cyclin E:CDK2 complexes by WEE1 - Homo sapiens [BlackBoxEvent:R-HSA-188345] The CDC25A gene transcription is stimulated by MYC and E2F1 and inhibited by the DREAM complex - Homo sapiens
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:165074] Manfredi, James J
revised	[InstanceEdit:188346] Matthews, L, 2006-10-10 08:05:07
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-69199
summation	[Summation:213352] Cdc25A dephosphorylates Cdk2 and activates cyclin E-Cdk2 and...
updateTrackers	[UpdateTracker:9792023] Update Tracker - [Reaction:69199] Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A - v24:[addSummation]

Referrals

(updatedInstance)	[UpdateTracker:9792023] Update Tracker - [Reaction:69199] Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A - v24:[addSummation]
(replacementInstances)	[Deleted:737637] Deletion of instance: 69693 [Deleted:737644] Deletion of instance: 69694
(precedingEvent)	[Pathway:R-HSA-69200] Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes [Reaction:R-HSA-188350] CAK-mediated phosphorylation of Cyclin E:Cdk2 [Reaction:R-HSA-69562] Inactivation of Cyclin E:Cdk2 complexes by p27/p21 [NegativePrecedingEvent:9763996] Futile Cycle: Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A
(hasEvent)	[Pathway:R-HSA-69202] Cyclin E associated events during G1/S transition

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