Reactome | PCBP4 modulates CDKN1A translation

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PCBP4 modulates CDKN1A translation Show undefined attributes

authored	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
category	omitted
compartment	[Compartment:70101] cytosol [Compartment:7660] nucleoplasm
created	[InstanceEdit:6803413] Orlic-Milacic, Marija, 2015-10-06
dbId	6803411
displayName	PCBP4 modulates CDKN1A translation
edited	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14 [InstanceEdit:9627016] Orlic-Milacic, Marija, 2018-10-31
eventOf	[Pathway:R-HSA-69895] Transcriptional activation of cell cycle inhibitor p21 - Homo sapiens [Pathway:R-HSA-9617828] FOXO-mediated transcription of cell cycle genes - Homo sapiens [Pathway:R-HSA-6804116] TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest - Homo sapiens
followingEvent	[Reaction:R-HSA-187934] Inactivation of Cyclin A:Cdk2 complexes by p27/p21 - Homo sapiens [Reaction:R-HSA-69562] Inactivation of Cyclin E:Cdk2 complexes by p27/p21 - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-6803386] CDKN1A mRNA [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:6803408] The cyclin-dependent kinase inhibitor p21 is regulated by RNA-binding protein PCBP4 via mRNA stability
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	PCBP4 modulates CDKN1A translation
output	[EntityWithAccessionedSequence:R-HSA-182585] CDKN1A [nucleoplasm]
precedingEvent	[Reaction:R-HSA-6803403] PCBP4 binds the CDKN1A mRNA - Homo sapiens [BlackBoxEvent:R-HSA-6803388] TP53 stimulates CDKN1A (p21) transcription - Homo sapiens
regulatedBy	[NegativeRegulation:R-HSA-6803416] Negative regulation by 'PCBP4:CDKN1A mRNA [cytosol]'
regulationReference	[RegulationReference:9641267] Negative regulation by 'PCBP4:CDKN1A mRNA [cytosol]' The cyclin-dependent kinase inhibitor p21 is regulated by RNA-binding protein PCBP4 via mRNA stability
releaseDate	2016-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8855677] Zaccara, Sara, 2016-02-04 [InstanceEdit:8855680] Inga, Alberto, 2016-02-04 [InstanceEdit:9625979] Donlon, Timothy, 2018-10-17 [InstanceEdit:9626974] Bertaggia, Enrico, 2018-10-26
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-6803411
summation	[Summation:6803412] PCBP4 binding to the 3'-UTR of the CDKN1A (p21) mRNA reduces...

Referrals

(hasEvent)	[Pathway:R-HSA-9617828] FOXO-mediated transcription of cell cycle genes [Pathway:R-HSA-6804116] TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest [Pathway:R-HSA-69895] Transcriptional activation of cell cycle inhibitor p21
(precedingEvent)	[Reaction:R-HSA-187934] Inactivation of Cyclin A:Cdk2 complexes by p27/p21 [Reaction:R-HSA-69562] Inactivation of Cyclin E:Cdk2 complexes by p27/p21