Reactome | Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21

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Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21 Show undefined attributes

authored	[InstanceEdit:187509] Pagano, M, 2006-09-19 08:23:10
catalystActivity	[CatalystActivity:187499] cyclin-dependent protein serine/threonine kinase activity of Cyclin E/A:p-T160-CDK2:CDKN1A,CDKN1B [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:187528] Matthews, L, 2006-09-20 10:11:50
dbId	187520
deleted	[Deleted:737633] Deletion of instance: 188178
displayName	Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21
edited	[InstanceEdit:187502] Matthews, L, 2006-09-19 08:32:00
eventOf	[Pathway:R-HSA-187577] SCF(Skp2)-mediated degradation of p27/p21 - Homo sapiens
followingEvent	[Reaction:R-HSA-187552] Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex - Homo sapiens
input	[SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [Complex:R-HSA-187516] Cyclin E/A:p-T160-CDK2:CDKN1A,CDKN1B [nucleoplasm]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:187515] Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation [LiteratureReference:187523] p27(Kip1) ubiquitination and degradation is regulated by the SCF(Skp2) complex through phosphorylated Thr187 in p27 [LiteratureReference:187517] SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21
orthologousEvent	[Reaction:R-CEL-187520] Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21 - Caenorhabditis elegans [Reaction:R-DME-187520] Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21 - Drosophila melanogaster [Reaction:R-GGA-187520] Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21 - Gallus gallus [Reaction:R-XTR-187520] Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21 - Xenopus tropicalis [Reaction:R-DRE-187520] Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21 - Danio rerio [Reaction:R-SSC-187520] Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21 - Sus scrofa [Reaction:R-BTA-187520] Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21 - Bos taurus [Reaction:R-CFA-187520] Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21 - Canis familiaris [Reaction:R-RNO-187520] Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21 - Rattus norvegicus [Reaction:R-MMU-187520] Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21 - Mus musculus
output	[SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [Complex:R-HSA-187522] Cyclin E/A:p-T160-CDK2:p-S130-CDKN1A,p-T187-CDKN1B [nucleoplasm]
precedingEvent	[Reaction:R-HSA-187934] Inactivation of Cyclin A:Cdk2 complexes by p27/p21 - Homo sapiens [Reaction:R-HSA-69562] Inactivation of Cyclin E:Cdk2 complexes by p27/p21 - Homo sapiens
releaseDate	2006-11-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:188313] Coqueret, O, 2006-10-06 08:59:06
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-187520
summation	[Summation:187524] The interaction between the Skp2 subunit of the SCF(Skp2) co...

Referrals

(replacementInstances)	[Deleted:737633] Deletion of instance: 188178
(hasEvent)	[Pathway:R-HSA-187577] SCF(Skp2)-mediated degradation of p27/p21
(precedingEvent)	[Reaction:R-HSA-187552] Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex