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Schema
>
BlackBoxEvent
>
Entries
CDC6 gene expression is stimulated by E2F1 and repressed by the DREAM complex
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authored
[InstanceEdit:113696] Gopinathrao, G, 2004-06-16 19:22:00
category
omitted
compartment
[Compartment:7660] nucleoplasm
created
[InstanceEdit:8961623] Orlic-Milacic, Marija, 2017-02-03
dbId
8961619
displayName
CDC6 gene expression is stimulated by E2F1 and repressed by the DREAM complex
edited
[InstanceEdit:8961898] Orlic-Milacic, Marija, 2017-02-06
eventOf
[Pathway:R-HSA-69205] G1/S-Specific Transcription - Homo sapiens
[Pathway:R-HSA-1362277] Transcription of E2F targets under negative control by DREAM complex - Homo sapiens
followingEvent
[Reaction:R-HSA-68688] CDC6 association with ORC(1-6) at replication origins - Homo sapiens
input
[EntityWithAccessionedSequence:R-HSA-8961618] CDC6 gene [nucleoplasm]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:68682] Cdc6 is regulated by E2F and is essential for DNA replication in mammalian cells
[LiteratureReference:113663] Regulation of cell growth-dependent expression of mammalian CDC6 gene by the cell cycle transcription factor E2F.
[LiteratureReference:1362256] Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence
modified
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name
CDC6 gene expression is stimulated by E2F1 and repressed by the DREAM complex
output
[EntityWithAccessionedSequence:R-HSA-68542] CDC6 [nucleoplasm]
precedingEvent
[Reaction:R-HSA-8961620] E2F1 binds the CDC6 gene promoter - Homo sapiens
[Reaction:R-HSA-8964498] DREAM complex binds the CDC6 gene promoter - Homo sapiens
regulatedBy
[PositiveGeneExpressionRegulation:R-HSA-539112] Positive gene expression regulation by 'E2F1:TFDP1,TFDP2:CDC6 gene [nucleoplasm]'
[NegativeGeneExpressionRegulation:R-HSA-8964507] Negative gene expression regulation by 'DREAM complex:CDC6 gene [nucleoplasm]'
regulationReference
[RegulationReference:9641835] Negative gene expression regulation by 'DREAM complex:CDC6 gene [nucleoplasm]' Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence
releaseDate
2009-09-30
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:113697] Bosco, G, 2004-06-16 19:24:21
[InstanceEdit:1538129] MacPherson, D, 2011-08-25
revised
[InstanceEdit:617365] Matthews, L, 2010-04-21
schemaClass
BlackBoxEvent
species
[Species:48887] Homo sapiens
stId
R-HSA-8961619
summation
[Summation:8961617] E2F1 directly stimulates transcription of the CDC6 gene (Yan...
Referrals
(hasEvent)
[Pathway:R-HSA-69205] G1/S-Specific Transcription
[Pathway:R-HSA-1362277] Transcription of E2F targets under negative control by DREAM complex
(precedingEvent)
[Reaction:R-HSA-68688] CDC6 association with ORC(1-6) at replication origins
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