created | [InstanceEdit:213369] Matthews, L, 2008-02-26 00:56:34 |
dbId | 213368 |
displayName | The E2F family of transcription factors regulate the transit... |
modified | [InstanceEdit:9632765] D'Eustachio, Peter, 2018-12-21 |
schemaClass | Summation |
text |
The E2F family of transcription factors regulate the transition from the G1 to the S phase in the cell cycle. E2F activity is regulated by members of the retinoblastoma protein (pRb) family, resulting in the tight control of the expression of E2F-responsive genes. Phosphorylation of pRb by cyclin D:CDK complexes releases pRb from E2F, inducing E2F-targeted genes such as cyclin E. E2F1 binds to E2F binding sites on the genome activating the synthesis of the target proteins. For annotation purposes, the reactions regulated by E2F1 are grouped under this pathway and information about the target genes alone are displayed for annotation purposes. |
(summation) |
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