Reactome | PCNA gene expression is stimulated by E2F1 and repressed by the DREAM complex

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PCNA gene expression is stimulated by E2F1 and repressed by the DREAM complex Show undefined attributes

authored	[InstanceEdit:113696] Gopinathrao, G, 2004-06-16 19:22:00
category	omitted
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:8961666] Orlic-Milacic, Marija, 2017-02-03
dbId	8961665
displayName	PCNA gene expression is stimulated by E2F1 and repressed by the DREAM complex
edited	[InstanceEdit:8961898] Orlic-Milacic, Marija, 2017-02-06
eventOf	[Pathway:R-HSA-69205] G1/S-Specific Transcription - Homo sapiens [Pathway:R-HSA-1362277] Transcription of E2F targets under negative control by DREAM complex - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-8961653] PCNA gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:141354] Cellular targets for activation by the E2F1 transcription factor include DNA synthesis- and G1/S-regulatory genes [LiteratureReference:8961656] An E2F site in the 5'-promoter region contributes to serum-dependent up-regulation of the human proliferating cell nuclear antigen gene [LiteratureReference:113623] Developmental control of a G1-S transcriptional program in Drosophila
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	PCNA gene expression is stimulated by E2F1 and repressed by the DREAM complex
output	[EntityWithAccessionedSequence:R-HSA-68439] PCNA [nucleoplasm]
precedingEvent	[Reaction:R-HSA-8961651] E2F1 binds the PCNA gene promoter - Homo sapiens [Reaction:R-HSA-8964465] DREAM complex binds the PCNA gene promoter - Homo sapiens
regulatedBy	[PositiveGeneExpressionRegulation:R-HSA-8961663] Positive gene expression regulation by 'E2F1:TFDP1,TFDP2:PCNA gene [nucleoplasm]' [NegativeGeneExpressionRegulation:R-HSA-8964518] Negative gene expression regulation by 'DREAM complex:PCNA gene [nucleoplasm]'
regulationReference	[RegulationReference:9641787] Positive gene expression regulation by 'E2F1:TFDP1,TFDP2:PCNA gene [nucleoplasm]' Cellular targets for activation by the E2F1 transcription factor include DNA synthesis- and G1/S-regulatory genes [RegulationReference:9642359] Negative gene expression regulation by 'DREAM complex:PCNA gene [nucleoplasm]' Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence
releaseDate	2009-09-30
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:113697] Bosco, G, 2004-06-16 19:24:21 [InstanceEdit:1538129] MacPherson, D, 2011-08-25
revised	[InstanceEdit:617365] Matthews, L, 2010-04-21
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-8961665
summation	[Summation:8961664] E2F1 directly stimulates transcription of the PCNA gene, whi...

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