Reactome | RPA heterotrimer [nucleoplasm]

Schema > Complex > Entries

RPA heterotrimer [nucleoplasm] Show undefined attributes

compartment	[Compartment:7660] nucleoplasm
componentOf	[Complex:R-HSA-5653772] ISG:K164,ISG:K168-PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm] - Homo sapiens [Complex:R-HSA-5655467] PCNA:RPA:RFC:Damaged DNA Template [nucleoplasm] - Homo sapiens [Complex:R-HSA-5653761] DNA polymerase Y:MonoUb:K164,ISG:K164,ISG:K168-PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm] - Homo sapiens [Complex:R-HSA-912428] Meiotic Holliday Junction [nucleoplasm] - Homo sapiens [Complex:R-HSA-912507] Meiotic single-stranded DNA complex [nucleoplasm] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-5333051] RPA1 binds HSF1 - Homo sapiens [Reaction:R-HSA-5693542] Association of RPA complexes with ssDNA at resected DNA DSBs - Homo sapiens [Reaction:R-HSA-174445] RPA binds to the Flap on the C-strand - Homo sapiens [Reaction:R-HSA-176175] Stalling of DNA replication fork and RPA binding - Homo sapiens [Reaction:R-HSA-69140] RPA binds to the Flap - Homo sapiens [Reaction:R-HSA-5689317] Formation of the pre-incision complex in GG-NER - Homo sapiens [Reaction:R-HSA-6782138] ERCC5 and RPA bind TC-NER site - Homo sapiens [BlackBoxEvent:R-HSA-5358599] EXO1 interacting with MSH2:MSH6 excises single strand DNA containing a mismatch - Homo sapiens [BlackBoxEvent:R-HSA-5358619] EXO1 interacting with MSH2:MSH3 excises DNA strand containing an insertion/deletion loop (IDL) - Homo sapiens [Reaction:R-HSA-6788385] The complex of ATR and ATRIP is recruited to ICL-DNA - Homo sapiens [BlackBoxEvent:R-HSA-912503] Formation of meiotic single-stranded DNA invasion complex - Homo sapiens
dbId	68462
displayName	RPA heterotrimer [nucleoplasm]
goCellularComponent	[GO_CellularComponent:17169] DNA replication factor A complex
hasComponent	[EntityWithAccessionedSequence:R-HSA-68461] RPA1 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-68457] RPA2 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-68459] RPA3 [nucleoplasm]
inDisease	false
inferredTo	[Complex:R-MMU-68462] RPA heterotrimer [nucleoplasm] - Mus musculus [Complex:R-RNO-68462] RPA heterotrimer [nucleoplasm] - Rattus norvegicus [Complex:R-CFA-68462] RPA heterotrimer [nucleoplasm] - Canis familiaris [Complex:R-BTA-68462] RPA heterotrimer [nucleoplasm] - Bos taurus [Complex:R-SSC-68462] RPA heterotrimer [nucleoplasm] - Sus scrofa [Complex:R-DRE-68462] RPA heterotrimer [nucleoplasm] - Danio rerio [Complex:R-XTR-68462] RPA heterotrimer [nucleoplasm] - Xenopus tropicalis [Complex:R-GGA-68462] RPA heterotrimer [nucleoplasm] - Gallus gallus [Complex:R-DME-68462] RPA heterotrimer [nucleoplasm] - Drosophila melanogaster [Complex:R-CEL-68462] RPA heterotrimer [nucleoplasm] - Caenorhabditis elegans [Complex:R-DDI-68462] RPA heterotrimer [nucleoplasm] - Dictyostelium discoideum [Complex:R-SPO-68462] RPA heterotrimer [nucleoplasm] - Schizosaccharomyces pombe [Complex:R-SCE-68462] RPA heterotrimer [nucleoplasm] - Saccharomyces cerevisiae [Complex:R-PFA-68462] RPA heterotrimer [nucleoplasm] - Plasmodium falciparum
maxDepth	2
modified	[InstanceEdit:9983308] Weiser, Joel, 2026-02-22
name	RPA heterotrimer
positivelyRegulates	[PositiveRegulation:R-HSA-5333056] Positive regulation by 'RPA heterotrimer [nucleoplasm]'
producedByEvent	[Reaction:R-HSA-5358579] DNA polymerase delta polymerizes DNA across single stranded gap - Homo sapiens [Reaction:R-HSA-5687758] PPP4C:PPP4R2 dephosphorylates RPA2 - Homo sapiens [Reaction:R-HSA-174441] Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand - Homo sapiens [Reaction:R-HSA-69144] Removal of RNA primer and dissociation of RPA and Dna2 - Homo sapiens [BlackBoxEvent:R-HSA-912429] Resolution of meiotic holliday junction - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-68462

Referrals

(hasComponent)	[Complex:R-HSA-5655467] PCNA:RPA:RFC:Damaged DNA Template [nucleoplasm] [Complex:R-HSA-5653782] PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm] [Complex:R-HSA-5653772] ISG:K164,ISG:K168-PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm] [Complex:R-HSA-5653761] DNA polymerase Y:MonoUb:K164,ISG:K164,ISG:K168-PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm] [Complex:R-HSA-5653909] MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA)-DNA Template [nucleoplasm] [Complex:R-HSA-5333048] HSF1:RPA [nucleoplasm] [Complex:R-HSA-912507] Meiotic single-stranded DNA complex [nucleoplasm] [Complex:R-HSA-5693552] RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] [Complex:R-HSA-5651799] PCNA:POLD,POLE:RPA:RFC [nucleoplasm] [Complex:R-HSA-5651997] MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] [Complex:R-HSA-174436] Processive complex loaded on telomere:Okazaki fragment:Flap:RPA heterotrimer [nucleoplasm] [Complex:R-HSA-176293] RPA complexed to ssDNA [nucleoplasm] [Complex:R-HSA-68463] Processive complex:Okazaki fragment:Flap:RPA heterotrimer [nucleoplasm] [Complex:R-HSA-5691043] GG-NER pre-incision complex:Open bubble-dsDNA [nucleoplasm] [Complex:R-HSA-5691059] GG-NER incision complex:5'-incised damaged DNA [nucleoplasm] [Complex:R-HSA-6790530] (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] [Complex:R-HSA-6782134] TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] [Complex:R-HSA-6782205] TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] [Complex:R-HSA-6788386] FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA:RPA:ATR:ATRIP [nucleoplasm] [Complex:R-HSA-5358538] RPA:DNA containing single strand gap [nucleoplasm] [Complex:R-HSA-912428] Meiotic Holliday Junction [nucleoplasm] [Complex:R-HSA-912484] Meiotic D-loop complex [nucleoplasm]
(input)	[Reaction:R-HSA-5333051] RPA1 binds HSF1 [BlackBoxEvent:R-HSA-912503] Formation of meiotic single-stranded DNA invasion complex [Reaction:R-HSA-5693542] Association of RPA complexes with ssDNA at resected DNA DSBs [Reaction:R-HSA-174445] RPA binds to the Flap on the C-strand [Reaction:R-HSA-176175] Stalling of DNA replication fork and RPA binding [Reaction:R-HSA-69140] RPA binds to the Flap [Reaction:R-HSA-5689317] Formation of the pre-incision complex in GG-NER [Reaction:R-HSA-6782138] ERCC5 and RPA bind TC-NER site [Reaction:R-HSA-6788385] The complex of ATR and ATRIP is recruited to ICL-DNA [BlackBoxEvent:R-HSA-5358599] EXO1 interacting with MSH2:MSH6 excises single strand DNA containing a mismatch [BlackBoxEvent:R-HSA-5358619] EXO1 interacting with MSH2:MSH3 excises DNA strand containing an insertion/deletion loop (IDL)
(output)	[Reaction:R-HSA-5687758] PPP4C:PPP4R2 dephosphorylates RPA2 [Reaction:R-HSA-174441] Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand [Reaction:R-HSA-69144] Removal of RNA primer and dissociation of RPA and Dna2 [Reaction:R-HSA-5358579] DNA polymerase delta polymerizes DNA across single stranded gap [BlackBoxEvent:R-HSA-912429] Resolution of meiotic holliday junction
(regulator)	[PositiveRegulation:R-HSA-5333056] Positive regulation by 'RPA heterotrimer [nucleoplasm]'

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