Reactome | Formation of the pre-incision complex in GG-NER

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Formation of the pre-incision complex in GG-NER Show undefined attributes

authored	[InstanceEdit:73956] Joshi-Tope, G, 2003-07-14 15:01:00 [InstanceEdit:110275] Hoeijmakers, JH, 2004-01-29 18:08:33 [InstanceEdit:6783704] Orlic-Milacic, Marija, 2015-06-16
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5689316] Orlic-Milacic, Marija, 2015-04-22
dbId	5689317
deleted	[Deleted:6793244] Deletion of instance: 73936
displayName	Formation of the pre-incision complex in GG-NER
edited	[InstanceEdit:6783704] Orlic-Milacic, Marija, 2015-06-16
eventOf	[Pathway:R-HSA-5696395] Formation of Incision Complex in GG-NER - Homo sapiens
followingEvent	[Reaction:R-HSA-5690991] Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:17148] nucleotide-excision repair, preincision complex assembly
input	[EntityWithAccessionedSequence:R-HSA-67447] ERCC5 [nucleoplasm] [Complex:R-HSA-6790517] Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] [Complex:R-HSA-68462] RPA heterotrimer [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5689235] Solution structure of the DNA- and RPA-binding domain of the human repair factor XPA [LiteratureReference:5689231] RPA involvement in the damage-recognition and incision steps of nucleotide excision repair [LiteratureReference:5689499] DNA-binding polarity of human replication protein A positions nucleases in nucleotide excision repair [LiteratureReference:5689511] The spacer region of XPG mediates recruitment to nucleotide excision repair complexes and determines substrate specificity [LiteratureReference:5689523] Recruitment of the nucleotide excision repair endonuclease XPG to sites of UV-induced dna damage depends on functional TFIIH [LiteratureReference:5689525] XPG stabilizes TFIIH, allowing transactivation of nuclear receptors: implications for Cockayne syndrome in XP-G/CS patients
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	Formation of the pre-incision complex in GG-NER
orthologousEvent	[Reaction:R-MMU-5689317] Formation of the pre-incision complex in GG-NER - Mus musculus [Reaction:R-GGA-5689317] Formation of the pre-incision complex in GG-NER - Gallus gallus [Reaction:R-DRE-5689317] Formation of the pre-incision complex in GG-NER - Danio rerio [Reaction:R-SSC-5689317] Formation of the pre-incision complex in GG-NER - Sus scrofa [Reaction:R-BTA-5689317] Formation of the pre-incision complex in GG-NER - Bos taurus [Reaction:R-CFA-5689317] Formation of the pre-incision complex in GG-NER - Canis familiaris [Reaction:R-RNO-5689317] Formation of the pre-incision complex in GG-NER - Rattus norvegicus
output	[Complex:R-HSA-5691043] GG-NER pre-incision complex:Open bubble-dsDNA [nucleoplasm]
precedingEvent	[Reaction:R-HSA-6790487] RNF111 ubiquitinates SUMOylated XPC - Homo sapiens
releaseDate	2004-03-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:6790576] Fousteri, Maria, 2015-08-03
revised	[InstanceEdit:6783704] Orlic-Milacic, Marija, 2015-06-16
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5689317
summation	[Summation:5689502] Once an open bubble structure is generated in damaged dsDNA ...

Referrals

(replacementInstances)	[Deleted:6793244] Deletion of instance: 73936
(hasEvent)	[Pathway:R-HSA-5696395] Formation of Incision Complex in GG-NER
(precedingEvent)	[Reaction:R-HSA-5690991] Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER

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