Reactome | Removal of RNA primer and dissociation of RPA and Dna2

Schema > Reaction > Entries

Removal of RNA primer and dissociation of RPA and Dna2

Go to Details

category	dissociation
compartment	[Compartment:7660] nucleoplasm
dbId	69144
displayName	Removal of RNA primer and dissociation of RPA and Dna2
eventOf	[Pathway:R-HSA-69166] Removal of the Flap Intermediate - Homo sapiens
followingEvent	[Reaction:R-HSA-69152] Removal of remaining Flap - Homo sapiens
input	[Complex:R-HSA-68466] Processive complex:Okazaki fragment:Flap:RPA heterotrimer:dna2 [nucleoplasm]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:69131] RPA governs endonuclease switching during processing of Okazaki fragments in eucaryotes.
modified	[InstanceEdit:10306585] Shorser, Solomon, 2020-11-20
name	Removal of RNA primer and dissociation of RPA and Dna2
orthologousEvent	[Reaction:R-SSC-69144] Removal of RNA primer and dissociation of RPA and Dna2 - Sus scrofa [Reaction:R-RNO-69144] Removal of RNA primer and dissociation of RPA and Dna2 - Rattus norvegicus [Reaction:R-XTR-69144] Removal of RNA primer and dissociation of RPA and Dna2 - Xenopus tropicalis [Reaction:R-DRE-69144] Removal of RNA primer and dissociation of RPA and Dna2 - Danio rerio [Reaction:R-CFA-69144] Removal of RNA primer and dissociation of RPA and Dna2 - Canis familiaris [Reaction:R-MMU-69144] Removal of RNA primer and dissociation of RPA and Dna2 - Mus musculus
output	[SimpleEntity:R-ALL-164121] AMP [nucleoplasm] [SimpleEntity:R-ALL-418076] CMP [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-68465] DNA2 [nucleoplasm] [SimpleEntity:R-ALL-29626] GMP [nucleoplasm] [Complex:R-HSA-68468] Processive complex:Okazaki fragments:Remaining Flap [nucleoplasm] [Complex:R-HSA-68462] RPA heterotrimer [nucleoplasm] [SimpleEntity:R-ALL-418075] UMP [nucleoplasm]
precedingEvent	[Reaction:R-HSA-69142] Recruitment of Dna2 endonuclease - Homo sapiens
releaseDate	2004-07-06
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-69144
summation	[Summation:69145] The Dna2 endonuclease removes the initiator RNA along with s...

Referrals

(hasEvent)	[Pathway:R-HSA-69166] Removal of the Flap Intermediate - Homo sapiens
(precedingEvent)	[Reaction:R-HSA-69152] Removal of remaining Flap - Homo sapiens