Reactome | EXO1 interacting with MSH2:MSH6 excises single strand DNA containing a mismatch

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EXO1 interacting with MSH2:MSH6 excises single strand DNA containing a mismatch Show undefined attributes

authored	[InstanceEdit:5358529] May, B, 2014-03-28
catalystActivity	[CatalystActivity:5358637] 5'-3' exonuclease activity of EXO1:MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch and single strand incision [nucleoplasm]
category	omitted
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5358539] May, Bruce, 2014-03-30
dbId	5358599
displayName	EXO1 interacting with MSH2:MSH6 excises single strand DNA containing a mismatch
edited	[InstanceEdit:5358529] May, B, 2014-03-28
eventOf	[Pathway:R-HSA-5358565] Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) - Homo sapiens
followingEvent	[Reaction:R-HSA-5358579] DNA polymerase delta polymerizes DNA across single stranded gap - Homo sapiens
input	[Complex:R-HSA-5358633] EXO1:MLH1:PMS2:MSH2:MSH6:ATP:PCNA:DNA containing 1-2 base mismatch and single strand incision [nucleoplasm] [Complex:R-HSA-68462] RPA heterotrimer [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5358627] Analysis of the excision step in human DNA mismatch repair [LiteratureReference:5358580] Human mismatch repair: reconstitution of a nick-directed bidirectional reaction [LiteratureReference:5358604] Reconstitution of 5'-directed human mismatch repair in a purified system [LiteratureReference:5358562] A defined human system that supports bidirectional mismatch-provoked excision [LiteratureReference:5358548] Mechanism of 5'-directed excision in human mismatch repair [LiteratureReference:5358587] The evolutionarily conserved zinc finger motif in the largest subunit of human replication protein A is required for DNA replication and mismatch repair but not for nucleotide excision repair [LiteratureReference:5358575] Human strand-specific mismatch repair occurs by a bidirectional mechanism similar to that of the bacterial reaction [LiteratureReference:5358563] Partial reconstitution of human DNA mismatch repair in vitro: characterization of the role of human replication protein A [LiteratureReference:5358683] Human exonuclease I is required for 5' and 3' mismatch repair [LiteratureReference:5358656] Structures of human exonuclease 1 DNA complexes suggest a unified mechanism for nuclease family [LiteratureReference:69372] Replication protein A (RPA): the eukaryotic SSB.
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	EXO1 interacting with MSH2:MSH6 excises single strand DNA containing a mismatch
orthologousEvent	[BlackBoxEvent:R-HSA-5358619] EXO1 interacting with MSH2:MSH3 excises DNA strand containing an insertion/deletion loop (IDL) - Homo sapiens [BlackBoxEvent:R-MMU-5358599] EXO1 interacting with MSH2:MSH6 excises single strand DNA containing a mismatch - Mus musculus [BlackBoxEvent:R-GGA-5358599] EXO1 interacting with MSH2:MSH6 excises single strand DNA containing a mismatch - Gallus gallus [BlackBoxEvent:R-DRE-5358599] EXO1 interacting with MSH2:MSH6 excises single strand DNA containing a mismatch - Danio rerio [BlackBoxEvent:R-SSC-5358599] EXO1 interacting with MSH2:MSH6 excises single strand DNA containing a mismatch - Sus scrofa [BlackBoxEvent:R-BTA-5358599] EXO1 interacting with MSH2:MSH6 excises single strand DNA containing a mismatch - Bos taurus [BlackBoxEvent:R-CFA-5358599] EXO1 interacting with MSH2:MSH6 excises single strand DNA containing a mismatch - Canis familiaris [BlackBoxEvent:R-RNO-5358599] EXO1 interacting with MSH2:MSH6 excises single strand DNA containing a mismatch - Rattus norvegicus
output	[Complex:R-HSA-5358538] RPA:DNA containing single strand gap [nucleoplasm]
precedingEvent	[Reaction:R-HSA-5358597] EXO1 interacts with MSH2:MSH6 (MutSalpha) and MLH1:PMS2 (MutLalpha) - Homo sapiens
releaseDate	2014-06-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5566522] Edelbrock, Michael A, 2014-05-23
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-5358599
summation	[Summation:5358547] EXO1 exonucleolytically degrades the strand being repaired i...

Referrals

(hasEvent)	[Pathway:R-HSA-5358565] Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
(precedingEvent)	[Reaction:R-HSA-5358579] DNA polymerase delta polymerizes DNA across single stranded gap

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