Reactome | RPA heterotrimer [nucleoplasm]

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RPA heterotrimer [nucleoplasm] Show undefined attributes

compartment	[Compartment:7660] nucleoplasm
componentOf	[Complex:R-RNO-5653772] ISG:K164,ISG:K168-PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm] - Rattus norvegicus [Complex:R-RNO-5655467] PCNA:RPA:RFC:Damaged DNA Template [nucleoplasm] - Rattus norvegicus [Complex:R-RNO-5653761] DNA polymerase Y:MonoUb:K164,ISG:K164,ISG:K168-PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm] - Rattus norvegicus
consumedByEvent	[Reaction:R-RNO-5333051] RPA1 binds HSF1 - Rattus norvegicus [Reaction:R-RNO-5693542] Association of RPA complexes with ssDNA at resected DNA DSBs - Rattus norvegicus [BlackBoxEvent:R-RNO-5358599] EXO1 interacting with MSH2:MSH6 excises single strand DNA containing a mismatch - Rattus norvegicus [Reaction:R-RNO-5689317] Formation of the pre-incision complex in GG-NER - Rattus norvegicus [Reaction:R-RNO-6782138] ERCC5 and RPA bind TC-NER site - Rattus norvegicus [Reaction:R-RNO-69140] RPA binds to the Flap - Rattus norvegicus [Reaction:R-RNO-176175] Stalling of DNA replication fork and RPA binding - Rattus norvegicus [Reaction:R-RNO-174445] RPA binds to the Flap on the C-strand - Rattus norvegicus [Reaction:R-RNO-6788385] The complex of ATR and ATRIP is recruited to ICL-DNA - Rattus norvegicus
created	[InstanceEdit:9979708] Wright, Adam, 2024-03-07
dbId	9980664
displayName	RPA heterotrimer [nucleoplasm]
hasComponent	[EntityWithAccessionedSequence:R-RNO-68461] Rpa1 [nucleoplasm] [EntityWithAccessionedSequence:R-RNO-68457] Rpa2 [nucleoplasm] [EntityWithAccessionedSequence:R-RNO-68459] Rpa3 [nucleoplasm]
inDisease	false
inferredFrom	[Complex:R-HSA-68462] RPA heterotrimer [nucleoplasm] - Homo sapiens
name	RPA heterotrimer
producedByEvent	[Reaction:R-RNO-5358579] DNA polymerase delta polymerizes DNA across single stranded gap - Rattus norvegicus [Reaction:R-RNO-5687758] PPP4C:PPP4R2 dephosphorylates RPA2 - Rattus norvegicus [Reaction:R-RNO-69144] Removal of RNA primer and dissociation of RPA and Dna2 - Rattus norvegicus [Reaction:R-RNO-174441] Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand - Rattus norvegicus
schemaClass	Complex
species	[Species:48895] Rattus norvegicus
stId	R-RNO-68462
summation	[Summation:9864367] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Referrals

(hasComponent)	[Complex:R-RNO-5655467] PCNA:RPA:RFC:Damaged DNA Template [nucleoplasm] [Complex:R-RNO-5653782] PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm] [Complex:R-RNO-5653772] ISG:K164,ISG:K168-PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm] [Complex:R-RNO-5653761] DNA polymerase Y:MonoUb:K164,ISG:K164,ISG:K168-PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm] [Complex:R-RNO-5653909] MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA)-DNA Template [nucleoplasm] [Complex:R-RNO-5333048] HSF1:RPA [nucleoplasm] [Complex:R-RNO-5358538] RPA:DNA containing single strand gap [nucleoplasm] [Complex:R-RNO-6788386] FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA:RPA:ATR:ATRIP [nucleoplasm] [Complex:R-RNO-5691043] GG-NER pre-incision complex:Open bubble-dsDNA [nucleoplasm] [Complex:R-RNO-5691059] GG-NER incision complex:5'-incised damaged DNA [nucleoplasm] [Complex:R-RNO-6782134] TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] [Complex:R-RNO-6790530] (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] [Complex:R-RNO-6782205] TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] [Complex:R-RNO-68463] Processive complex:Okazaki fragment:Flap:RPA heterotrimer [nucleoplasm] [Complex:R-RNO-176293] RPA complexed to ssDNA [nucleoplasm] [Complex:R-RNO-174436] Processive complex loaded on telomere:Okazaki fragment:Flap:RPA heterotrimer [nucleoplasm] [Complex:R-RNO-5651997] MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] [Complex:R-RNO-5651799] PCNA:POLD,POLE:RPA:RFC [nucleoplasm] [Complex:R-RNO-5693552] RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm]
(input)	[Reaction:R-RNO-5333051] RPA1 binds HSF1 [BlackBoxEvent:R-RNO-5358599] EXO1 interacting with MSH2:MSH6 excises single strand DNA containing a mismatch [Reaction:R-RNO-6788385] The complex of ATR and ATRIP is recruited to ICL-DNA [Reaction:R-RNO-5689317] Formation of the pre-incision complex in GG-NER [Reaction:R-RNO-6782138] ERCC5 and RPA bind TC-NER site [Reaction:R-RNO-69140] RPA binds to the Flap [Reaction:R-RNO-176175] Stalling of DNA replication fork and RPA binding [Reaction:R-RNO-174445] RPA binds to the Flap on the C-strand [Reaction:R-RNO-5693542] Association of RPA complexes with ssDNA at resected DNA DSBs
(output)	[Reaction:R-RNO-5358579] DNA polymerase delta polymerizes DNA across single stranded gap [Reaction:R-RNO-69144] Removal of RNA primer and dissociation of RPA and Dna2 [Reaction:R-RNO-174441] Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand [Reaction:R-RNO-5687758] PPP4C:PPP4R2 dephosphorylates RPA2
(inferredTo)	[Complex:R-HSA-68462] RPA heterotrimer [nucleoplasm]

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