Reactome | Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand

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Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand

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authored	[InstanceEdit:176728] Blackburn, EH, Seidel, J, 2006-03-09 19:41:08
catalystActivity	[CatalystActivity:9669008] 5'-flap endonuclease activity of Processive complex loaded on telomere:Okazaki fragment:Flap:RPA heterotrimer:DNA2 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:174443] Gillespie, ME, 2006-02-17 20:47:42
dbId	174441
displayName	Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand
edited	[InstanceEdit:9686480] Orlic-Milacic, Marija, 2020-05-04
eventOf	[Pathway:R-HSA-174437] Removal of the Flap Intermediate from the C-strand - Homo sapiens
followingEvent	[Reaction:R-HSA-174446] Removal of remaining Flap from the C-strand - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:263978] telomere maintenance via semi-conservative replication
input	[Complex:R-HSA-174442] Processive complex loaded on telomere:Okazaki fragment:Flap:RPA heterotrimer:DNA2 [nucleoplasm]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9669004] Mammalian DNA2 helicase/nuclease cleaves G-quadruplex DNA and is required for telomere integrity [LiteratureReference:9668993] Processing of G4 DNA by Dna2 helicase/nuclease and replication protein A (RPA) provides insights into the mechanism of Dna2/RPA substrate recognition
modified	[InstanceEdit:10306585] Shorser, Solomon, 2020-11-20
name	Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand
orthologousEvent	[Reaction:R-DRE-174441] Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand - Danio rerio [Reaction:R-SSC-174441] Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand - Sus scrofa [Reaction:R-MMU-174441] Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand - Mus musculus [Reaction:R-XTR-174441] Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand - Xenopus tropicalis [Reaction:R-CFA-174441] Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand - Canis familiaris [Reaction:R-RNO-174441] Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand - Rattus norvegicus
output	[SimpleEntity:R-ALL-164121] AMP [nucleoplasm] [SimpleEntity:R-ALL-418076] CMP [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-68465] DNA2 [nucleoplasm] [SimpleEntity:R-ALL-29626] GMP [nucleoplasm] [Complex:R-HSA-174440] Processive complex loaded on telomere:Okazaki fragments:Remaining Flap [nucleoplasm] [Complex:R-HSA-68462] RPA heterotrimer [nucleoplasm] [SimpleEntity:R-ALL-418075] UMP [nucleoplasm]
precedingEvent	[Reaction:R-HSA-174451] Recruitment of DNA2 endonuclease to the C strand - Homo sapiens
releaseDate	2006-08-02
reviewed	[InstanceEdit:182786] Price, C, 2006-07-13 18:33:38 [InstanceEdit:9686481] Hayashi, Makoto T, 2020-04-29
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-174441
summation	[Summation:9669149] The DNA2 endonuclease removes the initiator RNA along with s...

Referrals

(hasEvent)	[Pathway:R-HSA-174437] Removal of the Flap Intermediate from the C-strand - Homo sapiens
(precedingEvent)	[Reaction:R-HSA-174446] Removal of remaining Flap from the C-strand - Homo sapiens