Reactome | RPA heterotrimer [nucleoplasm]

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RPA heterotrimer [nucleoplasm] Show undefined attributes

compartment	[Compartment:7660] nucleoplasm
componentOf	[Complex:R-SSC-5653772] ISG:K164,ISG:K168-PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm] - Sus scrofa [Complex:R-SSC-5655467] PCNA:RPA:RFC:Damaged DNA Template [nucleoplasm] - Sus scrofa [Complex:R-SSC-5653761] DNA polymerase Y:MonoUb:K164,ISG:K164,ISG:K168-PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm] - Sus scrofa
consumedByEvent	[Reaction:R-SSC-5333051] RPA1 binds HSF1 - Sus scrofa [Reaction:R-SSC-5693542] Association of RPA complexes with ssDNA at resected DNA DSBs - Sus scrofa [BlackBoxEvent:R-SSC-5358599] EXO1 interacting with MSH2:MSH6 excises single strand DNA containing a mismatch - Sus scrofa [Reaction:R-SSC-6782138] ERCC5 and RPA bind TC-NER site - Sus scrofa [Reaction:R-SSC-5689317] Formation of the pre-incision complex in GG-NER - Sus scrofa [Reaction:R-SSC-69140] RPA binds to the Flap - Sus scrofa [Reaction:R-SSC-176175] Stalling of DNA replication fork and RPA binding - Sus scrofa [Reaction:R-SSC-174445] RPA binds to the Flap on the C-strand - Sus scrofa [Reaction:R-SSC-6788385] The complex of ATR and ATRIP is recruited to ICL-DNA - Sus scrofa
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10447872
displayName	RPA heterotrimer [nucleoplasm]
hasComponent	[EntityWithAccessionedSequence:R-SSC-68461] RPA1 [nucleoplasm] [EntityWithAccessionedSequence:R-SSC-68457] RPA2 [nucleoplasm] [EntityWithAccessionedSequence:R-SSC-68459] RPA3 [nucleoplasm]
inDisease	false
inferredFrom	[Complex:R-HSA-68462] RPA heterotrimer [nucleoplasm] - Homo sapiens
maxDepth	2
name	RPA heterotrimer
producedByEvent	[Reaction:R-SSC-5358579] DNA polymerase delta polymerizes DNA across single stranded gap - Sus scrofa [Reaction:R-SSC-5687758] PPP4C:PPP4R2 dephosphorylates RPA2 - Sus scrofa [Reaction:R-SSC-69144] Removal of RNA primer and dissociation of RPA and Dna2 - Sus scrofa [Reaction:R-SSC-174441] Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand - Sus scrofa
schemaClass	Complex
species	[Species:49633] Sus scrofa
stId	R-SSC-68462
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Referrals

(hasComponent)	[Complex:R-SSC-5655467] PCNA:RPA:RFC:Damaged DNA Template [nucleoplasm] [Complex:R-SSC-5653782] PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm] [Complex:R-SSC-5653772] ISG:K164,ISG:K168-PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm] [Complex:R-SSC-5653761] DNA polymerase Y:MonoUb:K164,ISG:K164,ISG:K168-PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm] [Complex:R-SSC-5653909] MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA)-DNA Template [nucleoplasm] [Complex:R-SSC-5333048] HSF1:RPA [nucleoplasm] [Complex:R-SSC-5358538] RPA:DNA containing single strand gap [nucleoplasm] [Complex:R-SSC-6788386] FANCD2:FANCI:UBE2T:FA Core Complex:ICL-DNA:RPA:ATR:ATRIP [nucleoplasm] [Complex:R-SSC-6782205] TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] [Complex:R-SSC-6782134] TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] [Complex:R-SSC-6790530] (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] [Complex:R-SSC-5691059] GG-NER incision complex:5'-incised damaged DNA [nucleoplasm] [Complex:R-SSC-5691043] GG-NER pre-incision complex:Open bubble-dsDNA [nucleoplasm] [Complex:R-SSC-68463] Processive complex:Okazaki fragment:Flap:RPA heterotrimer [nucleoplasm] [Complex:R-SSC-176293] RPA complexed to ssDNA [nucleoplasm] [Complex:R-SSC-174436] Processive complex loaded on telomere:Okazaki fragment:Flap:RPA heterotrimer [nucleoplasm] [Complex:R-SSC-5651997] MonoUb:K164-PCNA:RPA:RFC [nucleoplasm] [Complex:R-SSC-5651799] PCNA:POLD,POLE:RPA:RFC [nucleoplasm] [Complex:R-SSC-5693552] RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm]
(input)	[Reaction:R-SSC-5333051] RPA1 binds HSF1 [BlackBoxEvent:R-SSC-5358599] EXO1 interacting with MSH2:MSH6 excises single strand DNA containing a mismatch [Reaction:R-SSC-6788385] The complex of ATR and ATRIP is recruited to ICL-DNA [Reaction:R-SSC-6782138] ERCC5 and RPA bind TC-NER site [Reaction:R-SSC-5689317] Formation of the pre-incision complex in GG-NER [Reaction:R-SSC-69140] RPA binds to the Flap [Reaction:R-SSC-176175] Stalling of DNA replication fork and RPA binding [Reaction:R-SSC-174445] RPA binds to the Flap on the C-strand [Reaction:R-SSC-5693542] Association of RPA complexes with ssDNA at resected DNA DSBs
(output)	[Reaction:R-SSC-5358579] DNA polymerase delta polymerizes DNA across single stranded gap [Reaction:R-SSC-69144] Removal of RNA primer and dissociation of RPA and Dna2 [Reaction:R-SSC-174441] Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand [Reaction:R-SSC-5687758] PPP4C:PPP4R2 dephosphorylates RPA2
(inferredTo)	[Complex:R-HSA-68462] RPA heterotrimer [nucleoplasm]

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