Reactome | Formation of the cornified envelope

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Formation of the cornified envelope Show undefined attributes

authored	[InstanceEdit:8863769] Jupe, Steve, 2016-03-10
created	[InstanceEdit:6809402] Jupe, Steve, 2015-11-11
dbId	6809371
displayName	Formation of the cornified envelope
edited	[InstanceEdit:8934545] Jupe, Steve, 2016-08-10
eventOf	[Pathway:R-HSA-6805567] Keratinization - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:396474] cornification
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-6810843] Envoplakin binds periplakin - Homo sapiens [Reaction:R-HSA-6814187] EVL:PPL heterodimer binds the inner surface of the plasma membrane - Homo sapiens [Reaction:R-HSA-6810899] TGM1 and involucrin bind the plasma membrane - Homo sapiens [BlackBoxEvent:R-HSA-6810894] Envoplakin, periplakin, involucrin, SPR binding mediated by TGM1 crosslinking - Homo sapiens [Reaction:R-HSA-8849797] Membrane proteases cleave Profilaggrin producing Filaggrin - Homo sapiens [Reaction:R-HSA-8934819] Cytoplasmic proteases cleave Profilaggrin producing Filaggrin - Homo sapiens [Reaction:R-HSA-8942224] Filaggrin binds Keratin tonofilament:Desmosome - Homo sapiens [Polymerisation:R-HSA-6810357] Fillagrin and keratin intermediate filaments polymerize forming a network - Homo sapiens [BlackBoxEvent:R-HSA-6811539] Reinforcement of the Cornified Envelope - Homo sapiens [Reaction:R-HSA-6810937] Lamellar bodies bind the early cornified envelope - Homo sapiens [Reaction:R-HSA-6814734] CDSN binds the cornified envelope - Homo sapiens [Reaction:R-HSA-6814298] Late envelope proteins bind cornified envelope:CDSN - Homo sapiens [Reaction:R-HSA-6814387] CASP14 cleaves filaggrin - Homo sapiens [BlackBoxEvent:R-HSA-6814764] Plasma membrane resorption - Homo sapiens [Reaction:R-HSA-6814695] PERP binds desmosomes - Homo sapiens [Reaction:R-HSA-6814374] Kazrin binds periplakin - Homo sapiens [Reaction:R-HSA-8849826] ST14 hydrolyzes and activates KLK5 - Homo sapiens [Reaction:R-HSA-8849646] SPINK5(490-624) binds KLK5 - Homo sapiens [Reaction:R-HSA-8849638] Dissociation of the SPINK5:KLK5 complex at low pH - Homo sapiens [Reaction:R-HSA-8849857] KLK5 cleaves and activates CELA2 - Homo sapiens [Reaction:R-HSA-8850831] KLK5 cleaves and activates KLK8 - Homo sapiens [Reaction:R-HSA-8850786] SPINK6 binds KLK12 - Homo sapiens [Reaction:R-HSA-8850797] SPINK6 binds KLK13 - Homo sapiens [Reaction:R-HSA-8850777] SPINK6 binds KLK14 - Homo sapiens [Reaction:R-HSA-8850794] SPINK6 binds KLK5 - Homo sapiens [Reaction:R-HSA-8850818] SPINK9 binds KLK5 - Homo sapiens [Reaction:R-HSA-6789310] LIPs hydrolyse TG to DAG and RCOOH - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2017-06-22
literatureReference	[LiteratureReference:6810349] The cornified envelope: a model of cell death in the skin
maxDepth	2
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	Formation of the cornified envelope
orthologousEvent	[Pathway:R-MMU-6809371] Formation of the cornified envelope - Mus musculus [Pathway:R-RNO-6809371] Formation of the cornified envelope - Rattus norvegicus [Pathway:R-CFA-6809371] Formation of the cornified envelope - Canis familiaris [Pathway:R-BTA-6809371] Formation of the cornified envelope - Bos taurus [Pathway:R-SSC-6809371] Formation of the cornified envelope - Sus scrofa [Pathway:R-DRE-6809371] Formation of the cornified envelope - Danio rerio [Pathway:R-XTR-6809371] Formation of the cornified envelope - Xenopus tropicalis [Pathway:R-GGA-6809371] Formation of the cornified envelope - Gallus gallus [Pathway:R-DME-6809371] Formation of the cornified envelope - Drosophila melanogaster [Pathway:R-CEL-6809371] Formation of the cornified envelope - Caenorhabditis elegans [Pathway:R-DDI-6809371] Formation of the cornified envelope - Dictyostelium discoideum [Pathway:R-PFA-6809371] Formation of the cornified envelope - Plasmodium falciparum
releaseDate	2016-09-19
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8934809] Blumenberg, Miroslav, 2016-08-12
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-6809371
summation	[Summation:6809396] As keratinocytes progress towards the upper epidermis, they ...
updateTrackers	[UpdateTracker:9782545] Update Tracker - [Pathway:6809371] Formation of the cornified envelope - v59:[addHasEvent, updateContainedRLE] [UpdateTracker:9781057] Update Tracker - [Pathway:6809371] Formation of the cornified envelope - v61:[addHasEvent]

Referrals

(hasEvent)	[Pathway:R-HSA-6805567] Keratinization
(updatedInstance)	[UpdateTracker:9782545] Update Tracker - [Pathway:6809371] Formation of the cornified envelope - v59:[addHasEvent, updateContainedRLE] [UpdateTracker:9781057] Update Tracker - [Pathway:6809371] Formation of the cornified envelope - v61:[addHasEvent]

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