Reactome | Formation of the cornified envelope

Schema > Pathway > Entries

Formation of the cornified envelope Show undefined attributes

created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10731020
displayName	Formation of the cornified envelope
eventOf	[Pathway:R-XTR-6805567] Keratinization - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:396474] cornification
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-XTR-6810843] Envoplakin binds periplakin - Xenopus tropicalis [Reaction:R-XTR-6814187] EVL:PPL heterodimer binds the inner surface of the plasma membrane - Xenopus tropicalis [Polymerisation:R-XTR-6810357] Fillagrin and keratin intermediate filaments polymerize forming a network - Xenopus tropicalis [Reaction:R-XTR-6814695] PERP binds desmosomes - Xenopus tropicalis [Reaction:R-XTR-6814374] Kazrin binds periplakin - Xenopus tropicalis
inferredFrom	[Pathway:R-HSA-6809371] Formation of the cornified envelope - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Formation of the cornified envelope
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-6809371
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-6805567] Keratinization
(inferredTo)	[Pathway:R-HSA-6809371] Formation of the cornified envelope

© 2026 Reactome

Cite Us!