Reactome | Dissociation of the SPINK5:KLK5 complex at low pH

Schema > Reaction > Entries

Dissociation of the SPINK5:KLK5 complex at low pH Show undefined attributes

authored	[InstanceEdit:8863769] Jupe, Steve, 2016-03-10
category	dissociation
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:8849615] D'Eustachio, Peter, 2015-12-16
dbId	8849638
displayName	Dissociation of the SPINK5:KLK5 complex at low pH
edited	[InstanceEdit:8934483] Jupe, Steve, 2016-08-09
eventOf	[Pathway:R-HSA-6809371] Formation of the cornified envelope - Homo sapiens
followingEvent	[Reaction:R-HSA-8849857] KLK5 cleaves and activates CELA2 - Homo sapiens
input	[Complex:R-HSA-8849656] KLK5:SPINK5 [extracellular region]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8849655] LEKTI fragments specifically inhibit KLK5, KLK7, and KLK14 and control desquamation through a pH-dependent interaction
maxDepth	1
modified	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
name	Dissociation of the SPINK5:KLK5 complex at low pH
orthologousEvent	[Reaction:R-SSC-8849638] Dissociation of the SPINK5:KLK5 complex at low pH - Sus scrofa [Reaction:R-BTA-8849638] Dissociation of the SPINK5:KLK5 complex at low pH - Bos taurus [Reaction:R-RNO-8849638] Dissociation of the SPINK5:KLK5 complex at low pH - Rattus norvegicus [Reaction:R-MMU-8849638] Dissociation of the SPINK5:KLK5 complex at low pH - Mus musculus
output	[EntityWithAccessionedSequence:R-HSA-8849629] KLK5 [extracellular region] [EntityWithAccessionedSequence:R-HSA-8849665] SPINK5(490-624) [extracellular region]
precedingEvent	[Reaction:R-HSA-8849646] SPINK5(490-624) binds KLK5 - Homo sapiens
regulatedBy	[Requirement:R-HSA-8849621] Requirement by 'H+ [extracellular region]'
regulationReference	[RegulationReference:9641689] Requirement by 'H+ [extracellular region]' LEKTI fragments specifically inhibit KLK5, KLK7, and KLK14 and control desquamation through a pH-dependent interaction
releaseDate	2016-09-19
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8934809] Blumenberg, Miroslav, 2016-08-12
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8849638
summation	[Summation:8849623] At low pH, the complex of the D8D9 fragment of SPINK5 (Serin...

Referrals

(hasEvent)	[Pathway:R-HSA-6809371] Formation of the cornified envelope
(precedingEvent)	[Reaction:R-HSA-8849857] KLK5 cleaves and activates CELA2

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