Reactome | Cytoplasmic proteases cleave Profilaggrin producing Filaggrin

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Cytoplasmic proteases cleave Profilaggrin producing Filaggrin Show undefined attributes

authored	[InstanceEdit:8863769] Jupe, Steve, 2016-03-10
catalystActivity	[CatalystActivity:8934826] endopeptidase activity of Cytoplasmic profilaggrin processing proteases [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:8934782] Jupe, Steve, 2016-08-12
dbId	8934819
displayName	Cytoplasmic proteases cleave Profilaggrin producing Filaggrin
edited	[InstanceEdit:8934545] Jupe, Steve, 2016-08-10
eventOf	[Pathway:R-HSA-6809371] Formation of the cornified envelope - Homo sapiens
followingEvent	[Reaction:R-HSA-8942224] Filaggrin binds Keratin tonofilament:Desmosome - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-8849818] FLG(1-4061) [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8847665] Caspase-14 protects against epidermal UVB photodamage and water loss [LiteratureReference:8934823] Cuts by caspase-14 control the proteolysis of filaggrin [LiteratureReference:8849795] Elastase 2 is expressed in human and mouse epidermis and impairs skin barrier function in Netherton syndrome through filaggrin and lipid misprocessing [LiteratureReference:8934808] Kallikrein-related peptidase 5 functions in proteolytic processing of profilaggrin in cultured human keratinocytes
maxDepth	1
modified	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
name	Cytoplasmic proteases cleave Profilaggrin producing Filaggrin
orthologousEvent	[Reaction:R-SSC-8934819] Cytoplasmic proteases cleave Profilaggrin producing Filaggrin - Sus scrofa [Reaction:R-CFA-8934819] Cytoplasmic proteases cleave Profilaggrin producing Filaggrin - Canis familiaris
output	[EntityWithAccessionedSequence:R-HSA-6810859] FLG(?-?) [cytosol]
releaseDate	2016-09-19
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8934809] Blumenberg, Miroslav, 2016-08-12
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8934819
summation	[Summation:8849790] Filaggrin is initially synthesized as a large, insoluble, hi...

Referrals

(hasEvent)	[Pathway:R-HSA-6809371] Formation of the cornified envelope
(precedingEvent)	[Reaction:R-HSA-8942224] Filaggrin binds Keratin tonofilament:Desmosome

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