Reactome | KLK5 cleaves and activates CELA2

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KLK5 cleaves and activates CELA2 Show undefined attributes

authored	[InstanceEdit:8863769] Jupe, Steve, 2016-03-10
catalystActivity	[CatalystActivity:8849630] serine-type endopeptidase activity of KLK5 [extracellular region]
catalystActivityReference	[CatalystActivityReference:9643530] serine-type endopeptidase activity of KLK5 [extracellular region] Proteinase-activated receptors, targets for kallikrein signaling
category	transition
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:8849860] D'Eustachio, Peter, 2015-12-17
dbId	8849857
displayName	KLK5 cleaves and activates CELA2
edited	[InstanceEdit:8934483] Jupe, Steve, 2016-08-09
eventOf	[Pathway:R-HSA-6809371] Formation of the cornified envelope - Homo sapiens
input	[SimpleEntity:R-ALL-109276] H2O [extracellular region] [EntityWithAccessionedSequence:R-HSA-8849859] proCELA2A [extracellular region]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8849795] Elastase 2 is expressed in human and mouse epidermis and impairs skin barrier function in Netherton syndrome through filaggrin and lipid misprocessing [LiteratureReference:8849655] LEKTI fragments specifically inhibit KLK5, KLK7, and KLK14 and control desquamation through a pH-dependent interaction
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	KLK5 cleaves and activates CELA2
orthologousEvent	[Reaction:R-GGA-8849857] KLK5 cleaves and activates CELA2 - Gallus gallus [Reaction:R-SSC-8849857] KLK5 cleaves and activates CELA2 - Sus scrofa [Reaction:R-BTA-8849857] KLK5 cleaves and activates CELA2 - Bos taurus [Reaction:R-RNO-8849857] KLK5 cleaves and activates CELA2 - Rattus norvegicus [Reaction:R-MMU-8849857] KLK5 cleaves and activates CELA2 - Mus musculus
output	[EntityWithAccessionedSequence:R-HSA-8849616] CELA2A [extracellular region] [EntityWithAccessionedSequence:R-HSA-8849856] CELA2A propeptide [extracellular region]
precedingEvent	[Reaction:R-HSA-8849638] Dissociation of the SPINK5:KLK5 complex at low pH - Homo sapiens
releaseDate	2016-09-19
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8934809] Blumenberg, Miroslav, 2016-08-12
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8849857
summation	[Summation:8849858] In the low-pH environment of the upper layers of the stratum...

Referrals

(hasEvent)

[Pathway:R-HSA-6809371] Formation of the cornified envelope