Reactome | KLK5 cleaves and activates KLK8

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KLK5 cleaves and activates KLK8 Show undefined attributes

authored	[InstanceEdit:8863769] Jupe, Steve, 2016-03-10
catalystActivity	[CatalystActivity:8849630] serine-type endopeptidase activity of KLK5 [extracellular region]
catalystActivityReference	[CatalystActivityReference:9643530] serine-type endopeptidase activity of KLK5 [extracellular region] Proteinase-activated receptors, targets for kallikrein signaling
category	transition
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:8850827] D'Eustachio, Peter, 2015-12-29
dbId	8850831
displayName	KLK5 cleaves and activates KLK8
edited	[InstanceEdit:8934483] Jupe, Steve, 2016-08-09
eventOf	[Pathway:R-HSA-6809371] Formation of the cornified envelope - Homo sapiens
input	[SimpleEntity:R-ALL-109276] H2O [extracellular region] [EntityWithAccessionedSequence:R-HSA-8850832] proKLK8 [extracellular region]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8850834] Kallikrein-related peptidase-8 (KLK8) is an active serine protease in human epidermis and sweat and is involved in a skin barrier proteolytic cascade [LiteratureReference:8850824] Kallikrein-8 Proteolytically Processes Human Papillomaviruses in the Extracellular Space To Facilitate Entry into Host Cells
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	KLK5 cleaves and activates KLK8
orthologousEvent	[Reaction:R-GGA-8850831] KLK5 cleaves and activates KLK8 - Gallus gallus [Reaction:R-SSC-8850831] KLK5 cleaves and activates KLK8 - Sus scrofa [Reaction:R-BTA-8850831] KLK5 cleaves and activates KLK8 - Bos taurus [Reaction:R-RNO-8850831] KLK5 cleaves and activates KLK8 - Rattus norvegicus [Reaction:R-MMU-8850831] KLK5 cleaves and activates KLK8 - Mus musculus
output	[EntityWithAccessionedSequence:R-HSA-8850833] KLK8 [extracellular region] [EntityWithAccessionedSequence:R-HSA-8850829] KLK8 propeptide [extracellular region]
releaseDate	2016-09-19
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8934809] Blumenberg, Miroslav, 2016-08-12
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8850831
summation	[Summation:8850826] In vitro, KLK5 (Kallikrein 5) catalyzes the slow cleavage of...

Referrals

(hasEvent)

[Pathway:R-HSA-6809371] Formation of the cornified envelope