Reactome | CASP14 cleaves filaggrin

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CASP14 cleaves filaggrin Show undefined attributes

authored	[InstanceEdit:8863769] Jupe, Steve, 2016-03-10
catalystActivity	[CatalystActivity:8847672] cysteine-type endopeptidase activity of CASP14 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:6814377] Jupe, Steve, 2015-11-26
dbId	6814387
displayName	CASP14 cleaves filaggrin
edited	[InstanceEdit:8934483] Jupe, Steve, 2016-08-09
eventOf	[Pathway:R-HSA-6809371] Formation of the cornified envelope - Homo sapiens
input	[Complex:R-HSA-6814275] Late cornified envelope [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8847665] Caspase-14 protects against epidermal UVB photodamage and water loss [LiteratureReference:8849800] Caspase-14 is required for filaggrin degradation to natural moisturizing factors in the skin
maxDepth	1
modified	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
name	CASP14 cleaves filaggrin
orthologousEvent	[Reaction:R-SSC-6814387] CASP14 cleaves filaggrin - Sus scrofa [Reaction:R-BTA-6814387] CASP14 cleaves filaggrin - Bos taurus [Reaction:R-CFA-6814387] CASP14 cleaves filaggrin - Canis familiaris [Reaction:R-RNO-6814387] CASP14 cleaves filaggrin - Rattus norvegicus [Reaction:R-MMU-6814387] CASP14 cleaves filaggrin - Mus musculus
output	[Complex:R-HSA-6814763] Mature cornified envelope [plasma membrane]
precedingEvent	[Reaction:R-HSA-6814298] Late envelope proteins bind cornified envelope:CDSN - Homo sapiens
releaseDate	2016-09-19
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8934809] Blumenberg, Miroslav, 2016-08-12
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-6814387
summation	[Summation:6814359] In fully cornified cells, filaggrin is degraded into free am...

Referrals

(hasEvent)

[Pathway:R-HSA-6809371] Formation of the cornified envelope

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