Reactome | TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain

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TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain Show undefined attributes

authored	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
created	[InstanceEdit:6803212] Orlic-Milacic, Marija, 2015-10-05
dbId	6803205
displayName	TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
edited	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
eventOf	[Pathway:R-HSA-5633008] TP53 Regulates Transcription of Cell Death Genes - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-5633295] TP53 binds the NDRG1 gene promoter - Homo sapiens [BlackBoxEvent:R-HSA-5633314] TP53 stimulates NDRG1 gene expression - Homo sapiens [Reaction:R-HSA-6791327] TP53 binds the BCL2L14 gene - Homo sapiens [BlackBoxEvent:R-HSA-6791323] TP53 stimulates BCL2L14 gene expression - Homo sapiens [Reaction:R-HSA-6797766] TP53 binds the BIRC5 gene - Homo sapiens [BlackBoxEvent:R-HSA-6797763] TP53 inhibits BIRC5 expression - Homo sapiens [Reaction:R-HSA-6799462] TP53 family members bind the TP53I3 (PIG3) gene promoter - Homo sapiens [BlackBoxEvent:R-HSA-6799441] TP53 stimulates expression of the TP53I3 (PIG3) gene - Homo sapiens [Reaction:R-HSA-6799466] TP53I3 dimerizes - Homo sapiens [Reaction:R-HSA-6799722] TP53I3 oxidoreductase generates unstable semiquinones - Homo sapiens [Reaction:R-HSA-6799733] Semiquinone reacts with oxygen - Homo sapiens [Reaction:R-HSA-6800253] TP53 binds the BCL6 gene - Homo sapiens [BlackBoxEvent:R-HSA-6800250] TP53 stimulates BCL6 expression - Homo sapiens [Reaction:R-HSA-6800836] TP53 or TP63 binds the PERP gene - Homo sapiens [BlackBoxEvent:R-HSA-6800816] TP53 or TP63 stimulates PERP gene expression - Homo sapiens [Reaction:R-HSA-6801087] TP53 binds the RABGGTA gene - Homo sapiens [BlackBoxEvent:R-HSA-6801089] TP53 stimulates RABGGTA expression - Homo sapiens [Reaction:R-HSA-6801101] RABGGTA binds RABGGTB - Homo sapiens [Reaction:R-HSA-6801109] CHM binds RGGT - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5633302] NDRG1 is necessary for p53-dependent apoptosis [LiteratureReference:6791335] Bcl-G, a novel pro-apoptotic member of the Bcl-2 family [LiteratureReference:6791332] Bcl-2 family member Bcl-G is not a proapoptotic protein [LiteratureReference:5633304] p53-dependent NDRG1 expression induces inhibition of intestinal epithelial cell proliferation but not apoptosis after polyamine depletion [LiteratureReference:6799447] A polymorphic microsatellite that mediates induction of PIG3 by p53 [LiteratureReference:6799772] ASPP proteins specifically stimulate the apoptotic function of p53 [LiteratureReference:6799791] ASPP1 and ASPP2: common activators of p53 family members [LiteratureReference:6800261] BCL6 is regulated by p53 through a response element frequently disrupted in B-cell non-Hodgkin lymphoma [LiteratureReference:6800238] BCL6 suppression of BCL2 via Miz1 and its disruption in diffuse large B cell lymphoma [LiteratureReference:6800838] PERP, an apoptosis-associated target of p53, is a novel member of the PMP-22/gas3 family [LiteratureReference:6800848] P53 apoptosis mediator PERP: localization, function and caspase activation in uveal melanoma [LiteratureReference:6801427] Perp is a mediator of p53-dependent apoptosis in diverse cell types [LiteratureReference:5628898] Identification of novel p53 target genes in ionizing radiation response [LiteratureReference:6800259] The BCL6 proto-oncogene suppresses p53 expression in germinal-centre B cells
maxDepth	2
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
orthologousEvent	[Pathway:R-MMU-6803205] TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain - Mus musculus [Pathway:R-RNO-6803205] TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain - Rattus norvegicus [Pathway:R-CFA-6803205] TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain - Canis familiaris [Pathway:R-BTA-6803205] TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain - Bos taurus [Pathway:R-SSC-6803205] TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain - Sus scrofa [Pathway:R-DRE-6803205] TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain - Danio rerio [Pathway:R-XTR-6803205] TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain - Xenopus tropicalis [Pathway:R-GGA-6803205] TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain - Gallus gallus [Pathway:R-DME-6803205] TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain - Drosophila melanogaster [Pathway:R-CEL-6803205] TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain - Caenorhabditis elegans [Pathway:R-DDI-6803205] TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain - Dictyostelium discoideum [Pathway:R-SPO-6803205] TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain - Schizosaccharomyces pombe [Pathway:R-SCE-6803205] TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain - Saccharomyces cerevisiae [Pathway:R-PFA-6803205] TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain - Plasmodium falciparum
releaseDate	2016-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8855677] Zaccara, Sara, 2016-02-04 [InstanceEdit:8855680] Inga, Alberto, 2016-02-04
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-6803205
summation	[Summation:6803209] The exact mechanisms of action of several other pro-apoptoti...

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[Pathway:R-HSA-5633008] TP53 Regulates Transcription of Cell Death Genes

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