Reactome | TP53 stimulates NDRG1 gene expression

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TP53 stimulates NDRG1 gene expression Show undefined attributes

authored	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
category	omitted
compartment	[Compartment:70101] cytosol [Compartment:7660] nucleoplasm
created	[InstanceEdit:5633313] Orlic-Milacic, Marija, 2014-10-31
dbId	5633314
displayName	TP53 stimulates NDRG1 gene expression
edited	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
eventOf	[Pathway:R-HSA-6803205] TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-5628853] NDRG1 Gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5633302] NDRG1 is necessary for p53-dependent apoptosis [LiteratureReference:5633304] p53-dependent NDRG1 expression induces inhibition of intestinal epithelial cell proliferation but not apoptosis after polyamine depletion [LiteratureReference:5633363] Metastasis suppressor, NDRG1, mediates its activity through signaling pathways and molecular motors [LiteratureReference:5633354] N-myc downstream-regulated gene 1: Diverse and complicated functions in human hepatocellular carcinoma (Review)
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	TP53 stimulates NDRG1 gene expression
output	[EntityWithAccessionedSequence:R-HSA-5628834] NDRG1 [cytosol]
precedingEvent	[Reaction:R-HSA-5633295] TP53 binds the NDRG1 gene promoter - Homo sapiens
regulatedBy	[PositiveGeneExpressionRegulation:R-HSA-5633316] Positive gene expression regulation by 'p-S15,S20-TP53 Tetramer:NDRG1 Gene [nucleoplasm]'
regulationReference	[RegulationReference:9642563] Positive gene expression regulation by 'p-S15,S20-TP53 Tetramer:NDRG1 Gene [nucleoplasm]' NDRG1 is necessary for p53-dependent apoptosis
releaseDate	2016-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8855677] Zaccara, Sara, 2016-02-04 [InstanceEdit:8855680] Inga, Alberto, 2016-02-04
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-5633314
summation	[Summation:5633315] Binding of TP53 (p53) to the NDRG1 gene promoter stimulates ...

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[Pathway:R-HSA-6803205] TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain