Reactome | TP53I3 oxidoreductase generates unstable semiquinones

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TP53I3 oxidoreductase generates unstable semiquinones Show undefined attributes

authored	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
catalystActivity	[CatalystActivity:6799729] quinone reductase (NADPH) activity of TP53I3 Dimer [cytosol]
catalystActivityReference	[CatalystActivityReference:9644083] NADPH:quinone reductase activity of TP53I3 Dimer [cytosol] Three-dimensional structure and enzymatic function of proapoptotic human p53-inducible quinone oxidoreductase PIG3
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:6799724] Orlic-Milacic, Marija, 2015-09-25
dbId	6799722
displayName	TP53I3 oxidoreductase generates unstable semiquinones
edited	[InstanceEdit:6804719] Orlic-Milacic, Marija, 2015-10-14
eventOf	[Pathway:R-HSA-6803205] TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain - Homo sapiens
followingEvent	[Reaction:R-HSA-6799733] Semiquinone reacts with oxygen - Homo sapiens
input	2 × [SimpleEntity:R-ALL-6799725] 1,2-Naphthoquinone [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29364] NADPH [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:6799444] Three-dimensional structure and enzymatic function of proapoptotic human p53-inducible quinone oxidoreductase PIG3
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	TP53I3 oxidoreductase generates unstable semiquinones
orthologousEvent	[Reaction:R-DDI-6799722] TP53I3 oxidoreductase generates unstable semiquinones - Dictyostelium discoideum [Reaction:R-GGA-6799722] TP53I3 oxidoreductase generates unstable semiquinones - Gallus gallus [Reaction:R-XTR-6799722] TP53I3 oxidoreductase generates unstable semiquinones - Xenopus tropicalis [Reaction:R-SSC-6799722] TP53I3 oxidoreductase generates unstable semiquinones - Sus scrofa [Reaction:R-BTA-6799722] TP53I3 oxidoreductase generates unstable semiquinones - Bos taurus [Reaction:R-CFA-6799722] TP53I3 oxidoreductase generates unstable semiquinones - Canis familiaris
output	[SimpleEntity:R-ALL-29366] NADP+ [cytosol] 2 × [SimpleEntity:R-ALL-6799726] semiquinone [cytosol]
precedingEvent	[Reaction:R-HSA-6799466] TP53I3 dimerizes - Homo sapiens
releaseDate	2016-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8855677] Zaccara, Sara, 2016-02-04 [InstanceEdit:8855680] Inga, Alberto, 2016-02-04
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-6799722
summation	[Summation:6799727] TP53I3 (PIG3) possesses a NADPH quinone reductase activity, ...

Referrals

(precedingEvent)	[Reaction:R-HSA-6799733] Semiquinone reacts with oxygen
(hasEvent)	[Pathway:R-HSA-6803205] TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain

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