Reactome | Activated MAPKs phosphorylate BRAF

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Activated MAPKs phosphorylate BRAF Show undefined attributes

authored	[InstanceEdit:5674528] Rothfels, Karen, 2015-02-12
catalystActivity	[CatalystActivity:5674493] protein serine/threonine kinase activity of p-T,Y MAPK monomers and dimers [cytosol]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:5675197] Rothfels, Karen, 2015-02-15
dbId	5675198
displayName	Activated MAPKs phosphorylate BRAF
edited	[InstanceEdit:5674528] Rothfels, Karen, 2015-02-12
eventOf	[Pathway:R-HSA-5674499] Negative feedback regulation of MAPK pathway - Homo sapiens
input	4 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [EntityWithAccessionedSequence:R-HSA-5672679] p-S446,T599,S602,S729 BRAF [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5672454] Impact of feedback phosphorylation and Raf heterodimerization on normal and mutant B-Raf signaling [LiteratureReference:5672524] Regulation and role of Raf-1/B-Raf heterodimerization [LiteratureReference:5674449] Identification of novel ERK-mediated feedback phosphorylation sites at the C-terminus of B-Raf
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	Activated MAPKs phosphorylate BRAF
orthologousEvent	[Reaction:R-DDI-5675198] Activated MAPKs phosphorylate BRAF - Dictyostelium discoideum [Reaction:R-CEL-5675198] Activated MAPKs phosphorylate BRAF - Caenorhabditis elegans [Reaction:R-DME-5675198] Activated MAPKs phosphorylate BRAF - Drosophila melanogaster [Reaction:R-GGA-5675198] Activated MAPKs phosphorylate BRAF - Gallus gallus [Reaction:R-DRE-5675198] Activated MAPKs phosphorylate BRAF - Danio rerio [Reaction:R-SSC-5675198] Activated MAPKs phosphorylate BRAF - Sus scrofa [Reaction:R-BTA-5675198] Activated MAPKs phosphorylate BRAF - Bos taurus [Reaction:R-CFA-5675198] Activated MAPKs phosphorylate BRAF - Canis familiaris [Reaction:R-RNO-5675198] Activated MAPKs phosphorylate BRAF - Rattus norvegicus [Reaction:R-MMU-5675198] Activated MAPKs phosphorylate BRAF - Mus musculus
output	4 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [EntityWithAccessionedSequence:R-HSA-5675199] hyperphosphorylated BRAF [plasma membrane]
releaseDate	2015-06-17
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5690572] Roskoski, Robert Jr, 2015-04-28
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5675198
summation	[Summation:5675200] BRAF is subject to MAPK-dependent phosphorylation that limit...

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(hasEvent)

[Pathway:R-HSA-5674499] Negative feedback regulation of MAPK pathway