Reactome | Negative feedback regulation of MAPK pathway

Schema > Pathway > Entries

created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10650078
displayName	Negative feedback regulation of MAPK pathway
eventOf	[Pathway:R-DRE-5675221] Negative regulation of MAPK pathway - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-DRE-5674496] Activated MAPKs phosphorylate MAP2K1 - Danio rerio [Reaction:R-DRE-5675194] Activated MAPK phosphorylates RAF1 - Danio rerio [Reaction:R-DRE-5675198] Activated MAPKs phosphorylate BRAF - Danio rerio
inferredFrom	[Pathway:R-HSA-5674499] Negative feedback regulation of MAPK pathway - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Negative feedback regulation of MAPK pathway
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:68323] Danio rerio
stId	R-DRE-5674499
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-DRE-5675221] Negative regulation of MAPK pathway
(inferredTo)	[Pathway:R-HSA-5674499] Negative feedback regulation of MAPK pathway

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