Reactome | Negative feedback regulation of MAPK pathway

Negative feedback regulation of MAPK pathway

Stable Identifier

R-HSA-5674499

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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Negative feedback regulation of MAPK pathway

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MAPK pathway activation is limited by a number of negative feedback loops established by MAPK-dependent phosphorylations. Known substrates of activated MAPK proteins that lie upstream in the RAF/MAPK pathway include SOS, RAF1, BRAF, and MAP2K1 (Buday et al, 1995; Dong et al, 1996; Dougherty et al, 2005; Sturm et al, 2010; Fritsche-Guenther et al, 2011; Rushworth et al, 2006; Brummer et al, 2003; Ritt et al, 2010; Catalanotti et al, 2009)

Literature References

PubMed ID	Title	Journal	Year
19933846	Impact of feedback phosphorylation and Raf heterodimerization on normal and mutant B-Raf signaling Ritt, DA, Monson, DM, Specht, SI, Morrison, DK	Mol. Cell. Biol.	2010
21613978	Strong negative feedback from Erk to Raf confers robustness to MAPK signalling Fritsche-Guenther, R, Witzel, F, Sieber, A, Herr, R, Schmidt, N, Braun, S, Brummer, T, Sers, C, Blüthgen, N	Mol. Syst. Biol.	2011
21177493	The mammalian MAPK/ERK pathway exhibits properties of a negative feedback amplifier Sturm, OE, Orton, R, Grindlay, J, Birtwistle, M, Vyshemirsky, V, Gilbert, D, Calder, M, Pitt, A, Kholodenko, B, Kolch, W	Sci Signal	2010
14654779	Identification of novel ERK-mediated feedback phosphorylation sites at the C-terminus of B-Raf Brummer, T, Naegele, H, Reth, M, Misawa, Y	Oncogene	2003
7478553	Downregulation of the Ras activation pathway by MAP kinase phosphorylation of Sos Buday, L, Warne, PH, Downward, J	Oncogene	1995
8626428	SOS phosphorylation and disassociation of the Grb2-SOS complex by the ERK and JNK signaling pathways Dong Chen, D C, Waters, SB, Holt, KH, Pessin, JE	J. Biol. Chem.	1996
16508002	Regulation and role of Raf-1/B-Raf heterodimerization Rushworth, LK, Hindley, AD, O'Neill, E, Kolch, W	Mol. Cell. Biol.	2006
19219045	A Mek1-Mek2 heterodimer determines the strength and duration of the Erk signal Catalanotti, F, Reyes, G, Jesenberger, V, Galabova-Kovacs, G, de Matos Simoes, R, Carugo, O, Baccarini, M	Nat. Struct. Mol. Biol.	2009
15664191	Regulation of Raf-1 by direct feedback phosphorylation Dougherty, MK, Müller, J, Ritt, DA, Zhou, M, Zhou, XZ, Copeland, TD, Conrads, TP, Veenstra, TD, Lu, KP, Morrison, DK	Mol. Cell	2005

Participants

Events

Participates

as an event of

Negative regulation of MAPK pathway (Homo sapiens)

Orthologous Events

Negative feedback regulation of MAPK pathway (Bos taurus)

Negative feedback regulation of MAPK pathway (Caenorhabditis elegans)

Negative feedback regulation of MAPK pathway (Canis familiaris)

Negative feedback regulation of MAPK pathway (Danio rerio)

Negative feedback regulation of MAPK pathway (Dictyostelium discoideum)

Negative feedback regulation of MAPK pathway (Drosophila melanogaster)

Negative feedback regulation of MAPK pathway (Gallus gallus)

Negative feedback regulation of MAPK pathway (Mus musculus)

Negative feedback regulation of MAPK pathway (Rattus norvegicus)

Negative feedback regulation of MAPK pathway (Sus scrofa)

Negative feedback regulation of MAPK pathway (Xenopus tropicalis)

Cross References

BioModels Database

BIOMD0000000652, BIOMD0000000648, BIOMD0000000655, BIOMD0000000654, BIOMD0000000175, BIOMD0000000255, BIOMD0000000477, BIOMD0000000653, BIOMD0000000656, BIOMD0000000424, BIOMD0000000019, BIOMD0000000288, BIOMD0000000149, BIOMD0000000651, BIOMD0000000557, BIOMD0000000251, BIOMD0000000883, BIOMD0000000664, BIOMD0000000659, BIOMD0000000399, BIOMD0000000832, BIOMD0000000427

Authored

Rothfels, K (2015-02-12)

Reviewed

Roskoski, R Jr (2015-04-29)

Created

Rothfels, K (2015-02-12)