Negative feedback regulation of MAPK pathway

Stable Identifier
Homo sapiens
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MAPK pathway activation is limited by a number of negative feedback loops established by MAPK-dependent phosphorylations. Known substrates of activated MAPK proteins that lie upstream in the RAF/MAPK pathway include SOS, RAF1, BRAF, and MAP2K1 (Buday et al, 1995; Dong et al, 1996; Dougherty et al, 2005; Sturm et al, 2010; Fritsche-Guenther et al, 2011; Rushworth et al, 2006; Brummer et al, 2003; Ritt et al, 2010; Catalanotti et al, 2009)

Literature References
PubMed ID Title Journal Year
15664191 Regulation of Raf-1 by direct feedback phosphorylation

Zhou, XZ, Veenstra, TD, Dougherty, MK, Lu, KP, Müller, J, Copeland, TD, Zhou, M, Morrison, DK, Conrads, TP, Ritt, DA

Mol. Cell 2005
19219045 A Mek1-Mek2 heterodimer determines the strength and duration of the Erk signal

Jesenberger, V, de Matos Simoes, R, Galabova-Kovacs, G, Baccarini, M, Reyes, G, Carugo, O, Catalanotti, F

Nat. Struct. Mol. Biol. 2009
16508002 Regulation and role of Raf-1/B-Raf heterodimerization

O'Neill, E, Rushworth, LK, Hindley, AD, Kolch, W

Mol. Cell. Biol. 2006
8626428 SOS phosphorylation and disassociation of the Grb2-SOS complex by the ERK and JNK signaling pathways

Pessin, JE, Dong Chen, D C, Holt, KH, Waters, SB

J. Biol. Chem. 1996
7478553 Downregulation of the Ras activation pathway by MAP kinase phosphorylation of Sos

Warne, PH, Buday, L, Downward, J

Oncogene 1995
14654779 Identification of novel ERK-mediated feedback phosphorylation sites at the C-terminus of B-Raf

Brummer, T, Naegele, H, Misawa, Y, Reth, M

Oncogene 2003
21177493 The mammalian MAPK/ERK pathway exhibits properties of a negative feedback amplifier

Calder, M, Sturm, OE, Vyshemirsky, V, Orton, R, Kholodenko, B, Gilbert, D, Birtwistle, M, Kolch, W, Grindlay, J, Pitt, A

Sci Signal 2010
21613978 Strong negative feedback from Erk to Raf confers robustness to MAPK signalling

Herr, R, Sieber, A, Sers, C, Fritsche-Guenther, R, Brummer, T, Braun, S, Schmidt, N, Witzel, F, Blüthgen, N

Mol. Syst. Biol. 2011
19933846 Impact of feedback phosphorylation and Raf heterodimerization on normal and mutant B-Raf signaling

Specht, SI, Monson, DM, Morrison, DK, Ritt, DA

Mol. Cell. Biol. 2010
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